Three-Component Reaction between 3-Acetylcoumarins, Amines, and Elemental Sulfur: A Designed Approach to 3-Amino-4 H -thieno[3,2- c ]coumarins.

Autor: Farajpour B; Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran., Heydarzadeh R; Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran., Hussain FHS; Medical Analysis Department, Applied Science Faculty, Tishk International University, Erbil 44001, Kurdistan Region, Iraq., Notash B; Department of Inorganic Chemistry, Shahid Beheshti University, Tehran 1983969411, Iran., Mirzaei P; Department of Organic Chemistry, Shahid Beheshti University, Tehran 1983969411, Iran., Shiri M; Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran.
Jazyk: angličtina
Zdroj: The Journal of organic chemistry [J Org Chem] 2024 Apr 05; Vol. 89 (7), pp. 4375-4383. Date of Electronic Publication: 2024 Mar 12.
DOI: 10.1021/acs.joc.3c02406
Abstrakt: In this work, a series of novel 3-amino-4 H -thieno[3,2- c ]coumarins were designed and synthesized by a one-pot, catalyst-free, and three-component reaction of 3-acetylcoumarins with amines and elemental sulfur. Readily available starting materials, simple heating conditions, facile installation of a sulfur atom into the molecule using S 8 as a sulfur source, acceptable functional group tolerance, and synthetically useful yields are some highlighted benefits of this process.
Databáze: MEDLINE