Sesquiterpene Acids and Lactones from Inula Confertiflora with their Antibacterial Activities.

Autor: Ahmed BH; Department of Chemistry, College of Natural and Computational Sciences, Addis Ababa University, P.O. Box, 1176, Addis Ababa, Ethiopia., Desta MA; Department of Chemistry, College of Natural and Computational Sciences, Addis Ababa University, P.O. Box, 1176, Addis Ababa, Ethiopia., Wami AA; Armauer Hansen Research Institute (AHRI), ALERT Hospital, Addis Ababa, Ethiopia., Beyene GT; Armauer Hansen Research Institute (AHRI), ALERT Hospital, Addis Ababa, Ethiopia., Bedane KG; Department of Chemistry, College of Natural and Computational Sciences, Addis Ababa University, P.O. Box, 1176, Addis Ababa, Ethiopia.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 May; Vol. 21 (5), pp. e202400265. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1002/cbdv.202400265
Abstrakt: The phytochemical investigation of the leaves of Inula confertiflora, a medicinal plant endemic to Ethiopia, led to the isolation of 15 terpenoids; 1β-hydroxy-α-costic acid (1), 3α-hydroxycostic acid (2), isotelekin (3), asperilin (4), carabrone (5), carpesioline (6), graveolide (7), inuviscolide (8), 8-epi-inuviscolide (9), 1β,4β-dihydroxy-5α(H)-guaia-10(14),11(13)-dien-8α,12-olide (10), isoinuviscolide (11), 4β,10β-dihydroxy-5α(H)-1,11(13)-guaidien-8α,12-olide (12), 4β,10β-dihydroxy-1β(H)-5α(H)-guai-11(13)-en-8α,12-olide (13), 4β,10α-dihydroxy-1β(H)-5α(H)-guai-11(13)-en-8α,12-olide (14), 4β,10α-dihydroxy-1α(H)-5α(H)-guai-11(13)-en-8α,12-olide (15). Herein, structural elucidation and full NMR data for compound 1 are presented for the first time. The structures were elucidated using NMR, HRESIMS, and by comparison with literature data. The relative configurations were defined by NOESY correlations and single-crystal X-ray crystallography. Herein, crystallography data of 6 and 7 were reported for the first time. The antibacterial efficacy of some of the isolated compounds was evaluated against two commonly dispersed environmental strains of Escherichia coli and Staphylococcus aureus. Compounds 1, 3, 6, 7, and 8 exhibited moderate antibacterial activities against the tested organisms. The chemotaxonomic significance of compounds is discussed.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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