| Autor: |
Nakahara H; Department of Industrial Pharmacy, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan., Hiranita T; Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.; Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA., Shibata O; Department of Biophysical Chemistry, Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki 859-3298, Japan. |
| Jazyk: |
angličtina |
| Zdroj: |
Langmuir : the ACS journal of surfaces and colloids [Langmuir] 2024 Mar 26; Vol. 40 (12), pp. 6484-6492. Date of Electronic Publication: 2024 Mar 12. |
| DOI: |
10.1021/acs.langmuir.4c00053 |
| Abstrakt: |
Interactions between the sigma 1 receptor agonist PRE-084 and various lipid monolayers, including dipalmitoylphosphatidylcholine (DPPC), DPP-ethanolamine (DPPE), DPP-glycerol (DPPG), DPP-serine (DPPS), palmitoylsphingomyelin (PSM), and cholesterol (Ch), were investigated to elucidate the effects of PRE-084 on membrane fluidity and stability. Their interactions with sigma 1 receptor agonists have potential implications for neuroprotection, antidepressant, analgesic, and cognitive enhancement effects. In this study, we observed that the presence of PRE-084 in the subphase led to increased fluidity in DPPC and DPPE monolayers, whereas decreasing fluidity was observed in DPPG, DPPS, and PSM monolayers. The interaction of PRE-084 with Ch monolayers was found to be distinct from its interaction with other lipids. Fluorescence microscopy images revealed changes in the size and shape of liquid-condensed domains in the presence of PRE-084, supporting the notion of altered membrane fluidity. Our findings provide new insights into the interaction of PRE-084 with lipid monolayers and its potential implications for biological and membrane science. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
