Unlocking the potential of oncology biomarkers: advancements in clinical theranostics.

Autor:	Dubey AK; Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, 34753 Sichuan University , Chengdu, P.R. China.; iGlobal Research and Publishing Foundation, New Delhi, India., Kaur I; Chitkara College of Pharmacy, 154025 Chitkara University Punjab , Rajpura, India., Madaan R; Chitkara College of Pharmacy, 154025 Chitkara University Punjab , Rajpura, India., Raheja S; Jan Nayak Ch. Devi Lal Memorial College of Pharmacy, Sirsa, Haryana, India., Bala R; Chitkara College of Pharmacy, 154025 Chitkara University Punjab , Rajpura, India., Garg M; Amity Institute of Molecular Medicine & Stem Cell Research, 77282 Amity University, Sector-125 , Noida, India., Kumar S; Department of Pharmaceutical Sciences and Drug Research, 429174 Punjabi University Patiala , Patiala, India., Lather V; Amity Institute of Pharmacy, 77282 Amity University , Noida, India., Mittal V; Department of Pharmaceutical Sciences, 29062 Maharshi Dayanand University , Rohtak, Haryana, India., Pandita D; Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, PushpVihar, 633274 Govt. of NCT of Delhi , New Delhi, India.; Centre for Advanced Formulation and Technology (CAFT), Delhi Pharmaceutical Sciences and Research University, PushpVihar, Govt. of NCT of Delhi, New Delhi, India., Gundamaraju R; ER Stress and Mucosal Immunology Lab, School of Health Sciences, 8785 University of Tasmania , Launceston, Tasmania, Australia.; School of Medicine, University of California San Francisco, San Francisco, CA, USA., Singla RK; Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, 34753 Sichuan University , Chengdu, P.R. China.; School of Pharmaceutical Sciences, 34753 Lovely Professional University , Phagwara, Punjab, India., Sharma R; Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, 80095 Banaras Hindu University , Varanasi, Uttar Pradesh, India.
Jazyk:	angličtina
Zdroj:	Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2024 Mar 12; Vol. 39 (1), pp. 5-20. Date of Electronic Publication: 2024 Mar 12 (Print Publication: 2024).
DOI:	10.1515/dmpt-2023-0056
Abstrakt:	Introduction: Cancer biomarkers have revolutionized the field of oncology by providing valuable insights into tumor changes and aiding in screening, diagnosis, prognosis, treatment prediction, and risk assessment. The emergence of "omic" technologies has enabled biomarkers to become reliable and accurate predictors of outcomes during cancer treatment. Content: In this review, we highlight the clinical utility of biomarkers in cancer identification and motivate researchers to establish a personalized/precision approach in oncology. By extending a multidisciplinary technology-based approach, biomarkers offer an alternative to traditional techniques, fulfilling the goal of cancer therapeutics to find a needle in a haystack. Summary and Outlook: We target different forms of cancer to establish a dynamic role of biomarkers in understanding the spectrum of malignancies and their biochemical and molecular characterization, emphasizing their prospective contribution to cancer screening. Biomarkers offer a promising avenue for the early detection of human cancers and the exploration of novel technologies to predict disease severity, facilitating maximum survival and minimum mortality rates. This review provides a comprehensive overview of the potential of biomarkers in oncology and highlights their prospects in advancing cancer diagnosis and treatment. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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