Retinal microvascular function and incidence and trajectories of clinically relevant depressive symptoms: the Maastricht Study.

Autor:	van Gennip ACE; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands., Gupta MD; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands., Houben AJHM; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands., Berendschot TTJM; School for Mental Health and Neuroscience, MHENS, Maastricht University, Maastricht, Netherlands.; Ophthalmology, Maastricht University Medical Centre, Maastricht, Netherlands.; School of Nutrition and Translational Research in Metabolism, NUTRIM, Maastricht University, Maastricht, Netherlands., Webers CAB; Ophthalmology, Maastricht University Medical Centre, Maastricht, Netherlands., van Greevenbroek MMJ; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands., van der Kallen CJH; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands., Koster A; Care and Public Health Research Institute, CAPHRI, Maastricht University, Maastricht, Netherlands.; Social Medicine, Maastricht University, Maastricht, Netherlands., Wesselius A; School of Nutrition and Translational Research in Metabolism, NUTRIM, Maastricht University, Maastricht, Netherlands.; Genetics and Cell Biology, Maastricht University Medical Centre, Maastricht, Netherlands., Eussen SJPM; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands.; Care and Public Health Research Institute, CAPHRI, Maastricht University, Maastricht, Netherlands.; Epidemiology, Maastricht University, Maastricht, Netherlands., Schalkwijk CG; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands., de Galan BE; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands.; Internal Medicine, Radboud University Medical Centre, Nijmegen, Netherlands., Köhler S; School for Mental Health and Neuroscience, MHENS, Maastricht University, Maastricht, Netherlands.; Psychiatry and Neuropsychology, Maastricht University, Maastricht, Netherlands., Schram MT; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands.; School for Mental Health and Neuroscience, MHENS, Maastricht University, Maastricht, Netherlands.; Heart and Vascular Centre, Maastricht University Medical Centre, Maastricht, Netherlands., Stehouwer CDA; Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.; School for Cardiovascular Diseases, CARIM, Maastricht University, Maastricht, Netherlands., van Sloten TT; Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2024 Jul; Vol. 54 (10), pp. 2482-2491. Date of Electronic Publication: 2024 Mar 12.
DOI:	10.1017/S0033291724000618
Abstrakt:	Background: Cerebral microvascular dysfunction may contribute to depression via disruption of brain structures involved in mood regulation, but evidence is limited. We investigated the association of retinal microvascular function, a proxy for microvascular function in the brain, with incidence and trajectories of clinically relevant depressive symptoms. Methods: Longitudinal data are from The Maastricht Study of 5952 participants (59.9 ± 8.5 years/49.7% women) without clinically relevant depressive symptoms at baseline (2010-2017). Central retinal arteriolar equivalent and central retinal venular equivalent (CRAE and CRVE) and a composite score of flicker light-induced retinal arteriolar and venular dilation were assessed at baseline. We assessed incidence and trajectories of clinically relevant depressive symptoms (9-item Patient Health Questionnaire score ⩾10). Trajectories included continuously low prevalence (low, n = 5225 [87.8%]); early increasing, then chronic high prevalence (early-chronic, n = 157 [2.6%]); low, then increasing prevalence (late-increasing, n = 247 [4.2%]); and remitting prevalence (remitting, n = 323 [5.4%]). Results: After a median follow-up of 7.0 years (range 1.0-11.0), 806 (13.5%) individuals had incident clinically relevant depressive symptoms. After full adjustment, a larger CRAE and CRVE were each associated with a lower risk of clinically relevant depressive symptoms (hazard ratios [HRs] per standard deviation [s.d.]: 0.89 [95% confidence interval (CI) 0.83-0.96] and 0.93 [0.86-0.99], respectively), while a lower flicker light-induced retinal dilation was associated with a higher risk of clinically relevant depressive symptoms (HR per s.d.: 1.10 [1.01-1.20]). Compared to the low trajectory, a larger CRAE was associated with lower odds of belonging to the early-chronic trajectory (OR: 0.83 [0.69-0.99]) and a lower flicker light-induced retinal dilation was associated with higher odds of belonging to the remitting trajectory (OR: 1.23 [1.07-1.43]). Conclusions: These findings support the hypothesis that cerebral microvascular dysfunction contributes to the development of depressive symptoms.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu