New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.

Autor: Telpoukhovskaia MA; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Murdy TJ; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Marola OJ; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Charland K; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., MacLean M; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Luquez T; Center for Translational and Computational Neuroimmunology Department of Neurology Columbia University Irving Medical Center New York New York USA., Lish AM; Ann Romney Center for Neurologic Diseases Department of Neurology Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA., Neuner S; Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA., Dunn A; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Onos KD; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Wiley J; Sage Bionetworks Seattle Washington USA., Archer D; Vanderbilt Memory and Alzheimer's Center Vanderbilt University Medical Center Nashville Tennessee USA.; Department of Neurology Vanderbilt University Medical Center Nashville Tennessee USA.; Vanderbilt Genetics Institute Vanderbilt University School of Medicine Nashville Tennessee USA., Huentelman MJ; Neurogenomics Division Translational Genomics Research Institute (TGen) Phoenix Arizona USA., Arnold M; Institute of Computational Biology Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg Germany.; Department of Psychiatry and Behavioral Sciences Duke University Durham North Carolina USA., Menon V; Center for Translational and Computational Neuroimmunology Department of Neurology Columbia University Irving Medical Center New York New York USA., Goate A; Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA., Van Eldik LJ; Sanders-Brown Center on Aging University of Kentucky Lexington Kentucky USA., Territo PR; Department of Medicine Division of Clinical Pharmacology Indiana University School of Medicine Indianapolis Indiana USA.; Stark Neuroscience Research Institute Indiana University School of Medicine Indianapolis Indiana USA., Howell GR; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.; Graduate School of Biomedical Science and Engineering University of Maine Orono Maine USA.; Neuroscience Program, Graduate School of Biomedical Science Tufts University School of Medicine Boston Massachusetts USA.; Genetics Program, Graduate School of Biomedical Science Tufts University School of Medicine Boston Massachusetts USA., Carter GW; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.; Graduate School of Biomedical Science and Engineering University of Maine Orono Maine USA.; Neuroscience Program, Graduate School of Biomedical Science Tufts University School of Medicine Boston Massachusetts USA.; Genetics Program, Graduate School of Biomedical Science Tufts University School of Medicine Boston Massachusetts USA., O'Connell KMS; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.; Graduate School of Biomedical Science and Engineering University of Maine Orono Maine USA.; Neuroscience Program, Graduate School of Biomedical Science Tufts University School of Medicine Boston Massachusetts USA.; Genetics Program, Graduate School of Biomedical Science Tufts University School of Medicine Boston Massachusetts USA., Kaczorowski CC; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.; Department of Neurology University of Michigan Ann Arbor Michigan USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2024 Mar 10; Vol. 10 (1), pp. e12458. Date of Electronic Publication: 2024 Mar 10 (Print Publication: 2024).
DOI: 10.1002/trc2.12458
Abstrakt: Introduction: In September 2022, The Jackson Laboratory Center for Alzheimer's and Dementia Research (JAX CADR) hosted a workshop with leading researchers in the Alzheimer's disease and related dementias (ADRD) field.
Methods: During the workshop, the participants brainstormed new directions to overcome current barriers to providing patients with effective ADRD therapeutics. The participants outlined specific areas of focus. Following the workshop, each group used standard literature search methods to provide background for each topic.
Results: The team of invited experts identified four key areas that can be collectively addressed to make a significant impact in the field: (1) Prioritize the diversification of disease targets, (2) enhance factors promoting resilience, (3) de-risk clinical pipeline, and (4) centralize data management.
Discussion: In this report, we review these four objectives and propose innovations to expedite ADRD therapeutic pipelines.
Competing Interests: Authors declare no conflict of interest. G.W.C. has consulted for Astex Therapeutics Ltd. Author disclosures are available in the Supporting Information.
(© 2024 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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