Antimalarial Effects of Nano Chloroquine Loaded Curcumin In vivo.

Autor:	Elmi T; Department of Laboratory Science, School of Medicine, Islamic Azad University, Babol Branch, Babol, Iran.; Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Tabatabaie F; Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Ardestani MS; Department of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran., Dalimi A; Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Ghaffarifar F; Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Zamani Z; Biochemistry Department, Pasteur Institute of Iran, Pasteur Avenue, Tehran. Iran., Maleki F; Department of Parasitology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Infectious disorders drug targets [Infect Disord Drug Targets] 2024; Vol. 24 (8), pp. e110324227851.
DOI:	10.2174/0118715265276270240222070244
Abstrakt:	Background: Malaria is still the deadliest parasitic disease caused by Plasmodium spp. Due to drug resistance and their unpleasant side effects, of conventional researchers are enormously seeking to achieve antimalarial drugs with more curative effective, less toxic and cost-affordable drugs using more advanced technology such as nanodrugs. Purpose: The present study aimed to examine the antimalarial effects of a novel synthesized nonochloroquine-loaded curcumin relying on dendrimer G2 in susceptible mice. Methods: Antimalarial activity and toxicity of the nanocomposite were examined on BALB/C mice with microscopy, checking RBCs morphology and related enzymatic activity rate. Results: The maximum inhibitory effect of the nanocomposite was seen at 10 mg/kg, killing 98% of P. berghei compared to sole chloroquine, whereas ED50 was reported at 5.5 mg/kg. The safety of the synthesized nanocomposite was confirmed with biochemical tests with no detrimental effects on mice. The sustainability and longevity of the nanodrug increased significantly with the NDC-CQ assay compared to the control groups. Conclusion: The study showed that nonochloroquine-loaded curcumin had a promising inhibitory effect on P. berghei growth in infected mice compared to standard drugs. However, further studies and clinical trials with large samples are recommended to study different aspects of using nanodrug. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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