The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.

Autor: Öhman J; Department of Experimental Medical Science, Lund University, Lund, Sweden., Sjölin E; Department of Experimental Medical Science, Lund University, Lund, Sweden., Cundari M; Department of Experimental Medical Science, Lund University, Lund, Sweden.; Unit of Neuropsychiatry, Hospital of Helsingborg, Helsingborg, Sweden.; Unit of Neurology, Hospital of Helsingborg, Helsingborg, Sweden., Johansson F; Department of Experimental Medical Science, Lund University, Lund, Sweden., Gilbert M; School of Psychology, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK., Boele HJ; Princeton Neuroscience Institute, Washington Road, Princeton, USA.; Department of Neuroscience, Erasmus MC, 3000 DR, Rotterdam, The Netherlands., Svensson P; Department of Experimental Medical Science, Lund University, Lund, Sweden., Rasmussen A; Department of Experimental Medical Science, Lund University, Lund, Sweden. anders.rasmussen@med.lu.se.
Jazyk: angličtina
Zdroj: Cerebellum (London, England) [Cerebellum] 2024 Oct; Vol. 23 (5), pp. 1859-1866. Date of Electronic Publication: 2024 Mar 11.
DOI: 10.1007/s12311-024-01682-1
Abstrakt: Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it did not reduce the number of EPSPs. The results suggest that nucleo-olivary stimulation does not influence the number of EPSPs in climbing fiber bursts.
(© 2024. The Author(s).)
Databáze: MEDLINE
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