Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's disease.

Autor: Summa KC; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. ksumma@northwestern.edu.; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA. ksumma@northwestern.edu., Jiang P; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA.; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, USA.; Neuroscience Discovery, Informatics and Predictive Sciences, Bristol Myers Squibb, Cambridge, MA, USA., González-Rodríguez P; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla and CIBERNED, Seville, Spain., Huang X; Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA., Lin X; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA.; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, USA., Vitaterna MH; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA.; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, USA., Dan Y; Department of Molecular & Cell Biology, University of California Berkeley, Berkeley, CA, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA., Turek FW; Center for Sleep & Circadian Biology, Northwestern University, Evanston, IL, USA.; Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL, USA.; The Ken & Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Department of Psychiatry & Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Mar 11; Vol. 10 (1), pp. 54. Date of Electronic Publication: 2024 Mar 11.
DOI: 10.1038/s41531-024-00670-w
Abstrakt: Disrupted sleep has a profound adverse impact on lives of Parkinson's disease (PD) patients and their caregivers. Sleep disturbances are exceedingly common in PD, with substantial heterogeneity in type, timing, and severity. Among the most common sleep-related symptoms reported by PD patients are insomnia, excessive daytime sleepiness, and sleep fragmentation, characterized by interruptions and decreased continuity of sleep. Alterations in brain wave activity, as measured on the electroencephalogram (EEG), also occur in PD, with changes in the pattern and relative contributions of different frequency bands of the EEG spectrum to overall EEG activity in different vigilance states consistently observed. The mechanisms underlying these PD-associated sleep-wake abnormalities are poorly understood, and they are ineffectively treated by conventional PD therapies. To help fill this gap in knowledge, a new progressive model of PD - the MCI-Park mouse - was studied. Near the transition to the parkinsonian state, these mice exhibited significantly altered sleep-wake regulation, including increased wakefulness, decreased non-rapid eye movement (NREM) sleep, increased sleep fragmentation, reduced rapid eye movement (REM) sleep, and altered EEG activity patterns. These sleep-wake abnormalities resemble those identified in PD patients. Thus, this model may help elucidate the circuit mechanisms underlying sleep disruption in PD and identify targets for novel therapeutic approaches.
(© 2024. The Author(s).)
Databáze: MEDLINE
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