[Surgical margins as prognostic factor in pelvis chondrosarcoma. Cohort study in a sarcoma unit].

Autor: Lizcano-Suárez AR; Departamento de Piel, Partes Blandas y Tumores Óseos. Instituto Nacional de Cancerología (México)., Clara-Altamirano MA; Departamento de Piel, Partes Blandas y Tumores Óseos. Instituto Nacional de Cancerología (México)., Velázquez-Rodríguez S; Departamento de Piel, Partes Blandas y Tumores Óseos. Instituto Nacional de Cancerología (México)., Martínez-Said H; Departamento de Piel, Partes Blandas y Tumores Óseos. Instituto Nacional de Cancerología (México)., Villavicencio-Valencia SV; Departamento de Piel, Partes Blandas y Tumores Óseos. Instituto Nacional de Cancerología (México)., García-Ortega DY; Departamento de Piel, Partes Blandas y Tumores Óseos. Instituto Nacional de Cancerología (México).
Jazyk: Spanish; Castilian
Zdroj: Acta ortopedica mexicana [Acta Ortop Mex] 2023 Nov-Dec; Vol. 37 (6), pp. 331-337.
Abstrakt: Introduction: chondrosarcoma is the second most common primary malignant tumor, constitutes approximately one quarter of all primary bone sarcomas. Surgical margins in pelvic chondrosarcoma have a direct impact as a prognostic factor, both on overall survival and on recurrence-free survival of this disease.
Objectives: to analyze the impact of surgical margins as a prognostic factor in pelvic chondrosarcoma.
Material and Methods: a retrospective database cohort with prospective follow-up of sarcomas in patients diagnosed with primary pelvic chondrosarcoma who underwent surgical treatment. Clinical-demographic variables were obtained, a descriptive analysis of each variable was performed, and these were contrasted with the outcome variables.
Results: seventeen patients were included, of which nine were female. The median age was 41 years, ranging from 23 to 65 years. The average tumor size was 20.9 cm (range 5 to 46 cm). The average surgical margin was 5.3 mm, ranging from 1 to 30 mm, with 58% positive margins. The average overall survival was 64 months (range 7 to 108 months). The distribution of pelvic involvement was as follows: zone I in nine patients (52.9%), zone II in two (11.8%), a combination of zones I-III in two (11.8%), I+II in one (5.9%), II+III in one (5.9%), I-III plus sacrum in one (5.9%) and I plus sacrum in one (5.9%). Tumor grades were classified as low in seven patients (41.2%), intermediate in sven (41.2%), high in two (11.8%), and dedifferentiated in one (5.9%). Regarding the type of resection, 12 patients (70.6%) underwent internal hemipelvectomy and five (29.4%) external hemipelvectomy. Recurrence was recorded in five cases (29.4%), metastasis in three (17.6%), and mortality in four (23.5%).
Conclusions: this series represents the largest cohort reported in Latin America of primary pelvic chondrosarcomas. A more favorable prognosis was observed in patients with surgical margins greater than 1 mm. The presence of chondrosarcoma in multiple pelvic zones was associated with a worse oncological prognosis. Additionally, a higher incidence of positive surgical margins and local recurrence rates were identified in pelvic chondrosarcomas compared to those located in the extremities.
Databáze: MEDLINE
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