Biological effects of diesel exhaust inhalation. III cardiovascular function.

Autor:	Krajnak K; Physical Effects Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Kan H; Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Thompson JA; Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA., McKinney W; Physical Effects Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Waugh S; Physical Effects Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA., South T; Physical Effects Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Burns D; Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Lebouf R; Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Cumpston J; Animal Facilities, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Boots T; Risk Evaluation Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA., Fedan JS; Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA.
Jazyk:	angličtina
Zdroj:	Inhalation toxicology [Inhal Toxicol] 2024 Mar; Vol. 36 (3), pp. 189-204. Date of Electronic Publication: 2024 Mar 11.
DOI:	10.1080/08958378.2024.2327364
Abstrakt:	Objective: Inhalation of diesel exhaust (DE) has been shown to be an occupational hazard in the transportation, mining, and gas and oil industries. DE also contributes to air pollution, and therefore, is a health hazard to the general public. Because of its effects on human health, changes have been made to diesel engines to reduce both the amounts of particulate matter and volatile fumes they generate. The goal of the current study was to examine the effects of inhalation of diesel exhaust. Materials and Methods: The study presented here specifically examines the effects of exposure to 0.2 and 1.0 mg/m 3 DE or filtered air (6h/d for 4 d) on measures of peripheral and cardio-vascular function, and biomarkers of heart and kidney dysfunction in male rats. A Tier 2 engine used in oil and gas fracking operations was used to generate the diesel exhaust. Results: Exposure to 0.2 mg/m 3 DE resulted in an increase in blood pressure 1d following the last exposure, and increases in dobutamine-induced cardiac output and stroke volume 1 and 27d after exposure. Changes in peripheral vascular responses to norepinephrine and acetylcholine were minimal as were changes in transcript expression in the heart and kidney. Exposure to 1.0 mg/m 3 DE did not result in major changes in blood pressure, measures of cardiac function, peripheral vascular function or transcript expression. Discussion and Conclusions: Based on the results of this study, we suggest that exposure to DE generated by a Tier 2 compliant diesel engine generates acute effects on biomarkers indicative of cardiovascular dysfunction. Recovery occurs quickly with most measures of vascular/cardiovascular function returning to baseline levels by 7d following exposure.
Databáze:	MEDLINE
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