Neurocognitive outcome and associated factors in long-term, adult survivors of childhood acute lymphoblastic leukemia, treated without cranial radiation therapy.

Autor:	Egset KS; Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway., Stubberud J; Department of Psychology, University of Oslo, Oslo, Norway.; Department of Research, Lovisenberg Diaconal Hospital, Oslo, Norway., Ruud E; Division for Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Hjort MA; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Children's Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Eilertsen MB; Department of Public Health and Nursing, Center for Health Promotion Research, Norwegian University of Science and Technology, Trondheim, Norway., Sund AM; Regional Centre for Child and Youth Mental Health and Child Welfare, Norwegian University of Science and Technology, Trondheim, Norway., Hjemdal O; Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway., Weider S; Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway., Reinfjell T; Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2024 Jul; Vol. 30 (6), pp. 523-532. Date of Electronic Publication: 2024 Mar 11.
DOI:	10.1017/S1355617724000080
Abstrakt:	Objective: There is limited research on neurocognitive outcome and associated risk factors in long-term, adult survivors of childhood acute lymphoblastic leukemia (ALL), without treatment of cranial radiation therapy. Moreover, the impact of fatigue severity and pain interference on neurocognition has received little attention. In this cross-sectional study, we examined neurocognitive outcome and associated factors in this population. Method: Intellectual abilities, verbal learning/memory, processing speed, attention, and executive functions were compared to normative means/medians with one sample t tests or Wilcoxon signed-rank tests. Associations with risk factors, fatigue severity, and pain interference were analyzed with linear regressions. Results: Long-term, adult survivors of childhood ALL ( N = 53, 51% females, mean age = 24.4 years, SD = 4.4, mean = 14.7 years post-diagnosis, SD = 3.4) demonstrated above average intellectual abilities, but performed below average in attention, inhibition, processing speed, and shifting ( p < 0.001). Executive functioning complaints were significantly higher than normative means, and positively associated with fatigue ( p < 0.001). There was no interaction between sex and fatigue and no neurocognitive impairments were associated with pain interference, risk group, age at diagnosis, or sex. Conclusions: Long-term, adult survivors of ALL treated without cranial radiation therapy, demonstrate domain-specific performance-based neurocognitive impairments. However, continued research on the neurocognitive outcome in this population as they age will be important in the coming years. Executive functioning complaints were frequently in the clinical range, and often accompanied by fatigue. This suggests a need for cognitive rehabilitation programs.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu