Engineering models of head and neck and oral cancers on-a-chip.
| Autor: | da Costa Sousa MG, Vignolo SM, Franca CM, Mereness J; Departments of Biomedical Engineering and Dermatology and Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Ave, Rochester, New York 14642, USA., Alves Fraga MA, Silva-Sousa AC; Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo. Av. do Café - Subsetor Oeste-11 (N-11), Ribeirão Preto, SP, 14040-904, Brazil., Benoit DSW, Bertassoni LE |
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| Jazyk: | angličtina |
| Zdroj: | Biomicrofluidics [Biomicrofluidics] 2024 Mar 06; Vol. 18 (2), pp. 021502. Date of Electronic Publication: 2024 Mar 06 (Print Publication: 2024). |
| DOI: | 10.1063/5.0186722 |
| Abstrakt: | Head and neck cancers (HNCs) rank as the sixth most common cancer globally and result in over 450 000 deaths annually. Despite considerable advancements in diagnostics and treatment, the 5-year survival rate for most types of HNCs remains below 50%. Poor prognoses are often attributed to tumor heterogeneity, drug resistance, and immunosuppression. These characteristics are difficult to replicate using in vitro or in vivo models, culminating in few effective approaches for early detection and therapeutic drug development. Organs-on-a-chip offer a promising avenue for studying HNCs, serving as microphysiological models that closely recapitulate the complexities of biological tissues within highly controllable microfluidic platforms. Such systems have gained interest as advanced experimental tools to investigate human pathophysiology and assess therapeutic efficacy, providing a deeper understanding of cancer pathophysiology. This review outlines current challenges and opportunities in replicating HNCs within microphysiological systems, focusing on mimicking the soft, glandular, and hard tissues of the head and neck. We further delve into the major applications of organ-on-a-chip models for HNCs, including fundamental research, drug discovery, translational approaches, and personalized medicine. This review emphasizes the integration of organs-on-a-chip into the repertoire of biological model systems available to researchers. This integration enables the exploration of unique aspects of HNCs, thereby accelerating discoveries with the potential to improve outcomes for HNC patients. Competing Interests: The authors have no conflicts to disclose. (© 2024 Author(s).) |
| Databáze: | MEDLINE |
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