Efficacy of metamizole to prevent kidney injury after renal-ischaemic reperfusion injury in Wistar rats.

Autor:	Kadar DD; Division of Urology., Warli SM; Division of Urology.; Department of Urology, Universitas Sumatera Utara Hospital, Universitas Sumatera Utara., Ritarwan K; Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara-Haji Adam Malik General Hospital., Ichwan M; Departments of Pharmacology and Therapeutics., Ismi J; Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala-Zainoel Abidin General Hospital, Banda Aceh, Indonesia., Fikri E; Division of Pediatric Surgery, Department of Surgery., Harahap J; Public Health., Alferraly I; Anatomical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Jan 12; Vol. 86 (3), pp. 1408-1415. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000001694
Abstrakt:	Background: Renal ischaemia-reperfusion injury (RIRI) is a common kidney procedure complication due to temporary blood flow interruption, leading to kidney injuries. This study aimed to analyze the effect of metamizole on the levels of interleukin-18 (IL-18), neutrophil-gelatinase-associated lipocalin (NGAL), myeloperoxidase (MPO), and histopathological changes in rats with RIRI. Materials and Methods: Animal pre-clinical design study was used. Thirty-two male Wistar rats (Rattus norvegicus) were divided into four groups: negative control, positive control, M100, and M200. Blood samples were collected by intracardiac puncture, followed by bilateral nephrectomy and analyzed histopathologically. Results: Significant difference in IL-18 levels between positive control vs negative control (114.1 + 12.07 vs. 94.0 + 11.4; P = 0.019) and positive control vs M100 (114.1 + 12.07 vs. 86.9 + 8.34; P = 0.007). There was no difference in NGAL. M100 group had the lowest serum MPO levels (14.78+2.01), there was a significant difference in MPO levels in all pairwise analyses. There was a difference in cumulative EGTI scores among the study groups [positive 10.5 (8-11) vs. negative 9 (7-10) vs. M100 9 (7-10) vs. M200 9 (7-11); P = 0.021]. Conclusion: Metamizole 100 mg/kgBW can reduce IL-18 and MPO levels in RIRI, giving more optimal results without affecting NGAL levels. Metamizole administration can reduce cumulative EGTI scores in RIRI, both at doses of 100 mg/kgBW and 200 mg/kgBW. This study shows that Metamizole can be used to prevent kidney injury caused by RIRI. IL-18 and MPO can be biomarkers in predicting kidney injury in RIRI. Competing Interests: None.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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