Evaluation of copeptin in children after stimulation with clonidine or L-Dopa.
| Autor: | Giannakopoulos A; Department of Pediatrics, Division of Endocrinology, Medical School, 69182 University of Patras , Patras, Greece., Kritikou D; Department of Pediatrics, Division of Endocrinology, Medical School, 69182 University of Patras , Patras, Greece., Chrysis D; Department of Pediatrics, Division of Endocrinology, Medical School, 69182 University of Patras , Patras, Greece. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2024 Mar 12; Vol. 37 (5), pp. 441-444. Date of Electronic Publication: 2024 Mar 12 (Print Publication: 2024). |
| DOI: | 10.1515/jpem-2024-0062 |
| Abstrakt: | Objectives: Arginine-stimulated serum copeptin has been proposed as a new method to diagnose arginine vasopressin (AVP) deficiency in children and adolescents. Herein we investigated the secretagogic potential of clonidine or L-Dopa on the copeptin serum levels in children. Methods: Eight stimulation tests (4 with clonidine and 4 with L-Dopa) were performed in eight children (5 boys and 3 girls) with a median age of 6.5 years-old, evaluated for short stature due to possible growth hormone deficiency. Serum copeptin levels were measured at 30, 60, 90, and 120 min after administration of clonidine or L-Dopa. Results: Copeptin levels in serum did not show any significant change in either test (clonidine or L-Dopa). The values of copeptin levels compared to the baseline value did not deviate more than 5 % in the clonidine arm (p=0.60) or 8 % in the L-Dopa arm (p=0.75) respectively. Conclusions: Data do not support the use of L-Dopa or clonidine as stimulants for evaluating AVP relating disorders in clinical pediatric practice. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|