Investigation of polymorphisms in BMP2, BMP4, SMAD6 and RUNX2 genes and pulp stones.

Autor: Thuller KABR; Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Antunes LAA; Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Postgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.; Specific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil., Kublitski PMO; Postgraduate Program in Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Paraná, Brazil., Brancher JA; Postgraduate Program in Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Paraná, Brazil., Baratto-Filho F; Department of Dentistry, Universidade da Região de Joinville, Joinville, Santa Catarina, Brazil.; School of Dentistry, Tuiuti University from Paraná, Curitiba, Paraná, Brazil., Küchler EC; School of Dentistry, Tuiuti University from Paraná, Curitiba, Paraná, Brazil.; Department of Orthodontics, University Hospital Bonn, Medical Faculty, Bonn, Germany., Silva-Sousa AC; Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Sousa-Neto MD; Department of Restorative Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil., Gabardo MCL; Postgraduate Program in Dentistry, School of Health Sciences, Universidade Positivo, Curitiba, Paraná, Brazil., Antunes LS; Postgraduate Program, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Postgraduate Program, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.; Specific Formation Department, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Australian endodontic journal : the journal of the Australian Society of Endodontology Inc [Aust Endod J] 2024 Aug; Vol. 50 (2), pp. 299-308. Date of Electronic Publication: 2024 Mar 10.
DOI: 10.1111/aej.12835
Abstrakt: This study aimed to assess the association between genetic polymorphisms in BMP2 (rs1005464 and rs235768), BMP4 (rs17563), SMAD6 (rs2119261 and rs3934908) and RUNX2 (rs59983488 and rs1200425) and pulp stones (PS). A total of 117 participants, consisting of 63 individuals with PS and 54 without PS, were included. Digital radiographs and a demographic/clinical questionnaire were used. Genomic DNA from salivary cells was genotyped via real-time polymerase chain reaction. Statistical analyses, including Chi-Square, Fisher's exact tests, Poisson regression and dimensionality reduction, were conducted. The rs2119261 polymorphism in the SMAD6 gene showed an association with genotype distribution in the recessive model (p = 0.049). The T-T haplotype in the SMAD6 gene (rs2119261 and rs3934908) was more prevalent in the control group and significantly linked with PS (p = 0.029). No associations were found between PS risk and genetic polymorphisms in BMP2, BMP4 and RUNX2. Polymorphisms in the SMAD6 gene were associated with PS.
(© 2024 Australian Society of Endodontology Inc.)
Databáze: MEDLINE
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