Short-term effect of intravitreal dexamethasone implant in refractory diabetic macular edema.

Autor: Moreno JB; Retina Department, Asociación para Evitar la Ceguera en México I.A.P., Mexico City, Mexico., Medina DB; Retina Department, Asociación para Evitar la Ceguera en México I.A.P., Mexico City, Mexico., Rosellón-Escobar MF; Retina Department, Asociación para Evitar la Ceguera en México I.A.P., Mexico City, Mexico.; School of Medicine and Health Sciences, Tecnológico de Monterrey, Mexico City, Mexico., García-Aguirre JG; Retina Department, Asociación para Evitar la Ceguera en México I.A.P., Mexico City, Mexico. jerry_gar_md@yahoo.com.; School of Medicine and Health Sciences, Tecnológico de Monterrey, Mexico City, Mexico. jerry_gar_md@yahoo.com.
Jazyk: angličtina
Zdroj: BMC ophthalmology [BMC Ophthalmol] 2024 Mar 11; Vol. 24 (1), pp. 113. Date of Electronic Publication: 2024 Mar 11.
DOI: 10.1186/s12886-024-03341-9
Abstrakt: Purpose: To evaluate the short-term effects (hours-days) of intravitreal dexamethasone implant (IDI) in eyes with diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (VEGF) injections.
Methods: This was a prospective, single-arm, interventional clinical series. Eyes with DME and 3-9 injections of ranibizumab without a good response were included. Patients underwent a single IDI. Best-corrected visual acuity (BCVA) measurement, complete ophthalmic evaluation, and spectral-domain optical coherence tomography (SD-OCT) were performed at baseline, 2 h, 3 h, 24 h, 7 days, and 1 month. The main outcomes were change in central retinal thickness (CRT) on SD-OCT and BCVA.
Results: Fifteen eyes of 15 patients were included. Mean CRT decreased after treatment from 515.87 µm ± 220.00 µm at baseline to 489.60 µm ± 176.53 µm after 2 h (p = 0.126), and 450.13 µm ± 163.43 at 24 h (p = 0.006). Change in BCVA was from 0.85 ± 0.44 logMAR baseline to 0.58 ± 0.37 log MAR at 1 month (p = 0.003).
Conclusions: Eyes treated with IDI showed significant decrease in CRT detectable 1 day after injection. In some patients, the effect could be observed 3 h post-implantation.
Trial Registration: Clinicaltrials.gov NCT05736081 . Registered 20 February 2023, Retrospectively registered.
(© 2024. The Author(s).)
Databáze: MEDLINE
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