2.5-Minute Fast Brain MRI with Multiple Contrasts in Acute Ischemic Stroke.

Autor: Kits A; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. annika.kits@regionstockholm.se.; Department of Neuroradiology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden. annika.kits@regionstockholm.se., Al-Saadi J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden., De Luca F; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden.; Department of Radiology, Karolinska University Hospital, Stockholm, Sweden., Janzon F; Department of Neuroradiology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden.; Department of Radiology, Danderyd Hospital, Stockholm, Sweden., Mazya MV; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neurology, Karolinska University Hospital, Stockholm, Sweden., Lundberg J; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden., Sprenger T; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; MR Applied Science Laboratory Europe, GE Healthcare, Stockholm, Sweden., Skare S; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden., Delgado AF; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Neuroradiology, Karolinska University Hospital, Solna, 17176, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Neuroradiology [Neuroradiology] 2024 May; Vol. 66 (5), pp. 737-747. Date of Electronic Publication: 2024 Mar 11.
DOI: 10.1007/s00234-024-03331-0
Abstrakt: Purpose: To assess the performance of a 2.5-minute multi-contrast brain MRI sequence (NeuroMix) in diagnosing acute cerebral infarctions.
Methods: Adult patients with a clinical suspicion of acute ischemic stroke were retrospectively included. Brain MRI at 3 T included NeuroMix and routine clinical MRI (cMRI) sequences, with DWI/ADC, T2-FLAIR, T2-weighted, T2*, SWI-EPI, and T1-weighted contrasts. Three radiologists (R1-3) independently assessed NeuroMix and cMRI for the presence of acute infarcts (DWI ↑, ADC = or ↓) and infarct-associated abnormalities on other image contrasts. Sensitivity, specificity, and the area under the receiver operating characteristic curve (AUC) were calculated and compared using DeLong's test. Inter- and intra-rater agreements were studied with kappa statistics. Relative DWI (rDWI) and T2-FLAIR (rT2-FLAIR) signal intensity for infarctions were semi-automatically rendered, and the correlation between methods was evaluated.
Results: According to the reference standard, acute infarction was present in 34 out of 44 (77%) patients (63 ± 17 years, 31 men). Other infarct-associated signal abnormalities were reported in similar frequencies on NeuroMix and cMRI (p > .08). Sensitivity for infarction detection was 94%, 100%, and 94% evaluated by R1, R2, R3, for NeuroMix and 94%, 100%, and 100% for cMRI. Specificity was 100%, 90%, and 100% for NeuroMix and 100%, 100%, and 100% for cMRI. AUC for NeuroMix was .97, .95, and .97 and .97, 1, and 1 for cMRI (DeLong p = 1, .32, .15), respectively. Inter- and intra-rater agreement was κ = .88-1. The correlation between NeuroMix and cMRI was R = .73 for rDWI and R = .83 for rT2-FLAIR.
Conclusion: Fast multi-contrast MRI NeuroMix has high diagnostic performance for detecting acute cerebral infarctions.
(© 2024. The Author(s).)
Databáze: MEDLINE
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