Age-associated reduction of sinus macrophages in human mesenteric lymph nodes.

Autor:	Kanemitsu K; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Yamada R; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan., Pan C; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Tsukamoto H; Division of Clinical Immunology and Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yano H; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Shiota T; Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan., Fujiwara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Miyamoto Y; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Mikami Y; Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan., Baba H; Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Komohara Y; Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Center for Metabolic Regulation of Healthy Aging, Kumamoto University, Kumamoto, Japan.
Jazyk:	angličtina
Zdroj:	Journal of clinical and experimental hematopathology : JCEH [J Clin Exp Hematop] 2024 Jun 27; Vol. 64 (2), pp. 79-85. Date of Electronic Publication: 2024 Mar 11.
DOI:	10.3960/jslrt.24001
Abstrakt:	There are numerous macrophages and dendritic cells in lymph nodes (LNs). Recent studies have highlighted that sinus macrophages (SMs) in LNs possess antigen-presenting capabilities and are related to anti-cancer immune responses. In this study, we assessed the distribution of SMs in mesenteric LNs removed during surgery for colorectal cancer. A marked reduction of SMs was noted in elderly patients, particularly those over 80 years old. We observed a disappearance of CD169-positive cells in LNs where SMs were reduced. In silico analysis of publicly available single-cell RNA sequencing data from LNs revealed that CD169-positive macrophages express numerous genes associated with antigen presentation and lymphocyte proliferation, similar to dendritic cells' functions. In conclusion, our study demonstrates that SMs, potentially crucial for immune activation, diminish in the LNs of elderly patients. This reduction of SMs may contribute to the immune dysfunction observed in the elderly.
Databáze:	MEDLINE
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