Alert for the high prevalence of vitamin D deficiency in adolescents in a large Brazilian sample.

Autor:	Radonsky V; Universidade Federal de São Paulo (UNIFESP), Departamento Endocrinologia, São Paulo, SP, Brazil., Lazaretti-Castro M; Universidade Federal de São Paulo (UNIFESP), Departamento Endocrinologia, São Paulo, SP, Brazil. Electronic address: marise.lazaretti@imabrasil.com.br., Chiamolera MI; Universidade Federal de São Paulo (UNIFESP), Departamento Endocrinologia, São Paulo, SP, Brazil; Grupo Fleury, Departamento Endocrinologia, São Paulo, SP, Brazil., Biscolla RPM; Universidade Federal de São Paulo (UNIFESP), Departamento Endocrinologia, São Paulo, SP, Brazil; Grupo Fleury, Departamento Endocrinologia, São Paulo, SP, Brazil., Lima Junior JV; Universidade Federal de São Paulo (UNIFESP), Departamento Endocrinologia, São Paulo, SP, Brazil; Grupo Fleury, Departamento Endocrinologia, São Paulo, SP, Brazil., Vieira JGH; Universidade Federal de São Paulo (UNIFESP), Departamento Endocrinologia, São Paulo, SP, Brazil; Grupo Fleury, Departamento Endocrinologia, São Paulo, SP, Brazil., Brandão CMA; Grupo Fleury, Departamento Endocrinologia, São Paulo, SP, Brazil., Ramalho RF; Grupo Fleury, Grupo de Ciências de Dados e Bioinformática, São Paulo, SP, Brazil., Maeda SS; Universidade Federal de São Paulo (UNIFESP), Departamento Endocrinologia, São Paulo, SP, Brazil., Cavichio MWE; Grupo Fleury, Departamento Pediatria, São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Jornal de pediatria [J Pediatr (Rio J)] 2024 Jul-Aug; Vol. 100 (4), pp. 360-366. Date of Electronic Publication: 2024 Mar 07.
DOI:	10.1016/j.jped.2024.01.003
Abstrakt:	Objective: To estimate the prevalence of vitamin D deficiency and severe deficiency in children and adolescents, in a large Brazilian sample. Methodology: Results of 413,988 25(OH)D measurements in children and adolescents aged 0 to 18 years collected between 01/2014 and 10/2018 were obtained from the database of a Clinical Laboratory. In this population, 25 hydroxyvitamin D concentrations below 20 ng/mL are considered deficient, and below 12 ng/mL as severe deficiency. All measurements were performed by immunoassay and the results were distributed by gender, age group, seasonality, and latitude. Results: The mean of 25(OH)D levels was 29.2 ng/mL with a standard deviation of 9.2 ng/mL. Of the total samples, 0.8% had a concentration < 12 ng/mL, and 12.5% of the samples had a concentration < 20 ng/mL, with a higher prevalence in females. Children under 2 years of age had the lowest prevalence. The effects of latitude and seasonality were quite evident. In samples of female adolescents from the southern region in winter, 36% of vitamin D deficiency and 5% of severe deficiency were found. Conclusion: In this large number of measurements of 25(OH)D in children and adolescents, 12.5% had a deficiency and 0.8% had severe deficiency. A greater deficiency was observed among adolescents, especially females, which raises questions about the need for supplementation during this period of life. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2024 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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