Oxidative stress and neurotoxicity induced by exposure to settleable atmospheric particulate matter in bullfrog tadpoles, Aquarana catesbeiana, (Shaw, 1802).

Autor: Fernandes IF; Programa de Pós-Graduação em Biotecnologia e Monitoramento Ambiental, Universidade Federal de São Carlos, Campus Sorocaba, Rodovia João Leme Dos Santos, Km 110, SP-264, Sorocaba, SP CEP 18052-780, Brazil., Fujiwara GH; Programa de Pós-Graduação em Biotecnologia e Monitoramento Ambiental, Universidade Federal de São Carlos, Campus Sorocaba, Rodovia João Leme Dos Santos, Km 110, SP-264, Sorocaba, SP CEP 18052-780, Brazil., Moraes Utsunomiya HS; Departamento de Biologia (DBio), Centro de Ciências Humanas e Biológicas (CCHB), Universidade Federal de São Carlos (UFSCar), 18052-780, São Carlos, São Paulo, Brazil., Souza IC; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil; Grupo de Mutagênese Ambiental, Departamento de Ciências Biológicas, Universidade Federal do Espírito Santo (DBV/UFES), Av. Fernando Ferrari, 514, 29075-910, Vitória, Espírito Santo, Brazil., Monteiro DA; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil., Monferrán MV; Departamento Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, and CONICET, CIBICI, Ciudad Universitaria, Medina Allende esq. Haya de la Torre s/n, 5000, Córdoba, Argentina; Instituto de Ciencia y Tecnología de Alimentos Córdoba (ICYTAC), CONICET and Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000, Córdoba, Argentina., Wunderlin DA; Instituto de Ciencia y Tecnología de Alimentos Córdoba (ICYTAC), CONICET and Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000, Córdoba, Argentina., Fernandes MN; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil., Carvalho CDS; Programa de Pós-Graduação em Biotecnologia e Monitoramento Ambiental, Universidade Federal de São Carlos, Campus Sorocaba, Rodovia João Leme Dos Santos, Km 110, SP-264, Sorocaba, SP CEP 18052-780, Brazil; Departamento de Biologia (DBio), Centro de Ciências Humanas e Biológicas (CCHB), Universidade Federal de São Carlos (UFSCar), 18052-780, São Carlos, São Paulo, Brazil. Electronic address: san-cleo@ufscar.br.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2024 Apr; Vol. 353, pp. 141576. Date of Electronic Publication: 2024 Mar 08.
DOI: 10.1016/j.chemosphere.2024.141576
Abstrakt: Bullfrog tadpoles, Aquarana catesbeiana, were exposed to settleable particulate matter (SePM), (1 g L -1 , 96 h) and their organs were collected for analysis of metal/metalloid, oxidative stress and neurotoxicity in liver, muscle, kidney and brain. The SePM water of the exposed groups contained 18 of the 28 metals/metalloids detected in ambient particulate matter (APM). Fe 56 and Al were those that presented the highest concentrations, Cr, Mn, Pb and Cu increased from 10 to 20 times and Ti, V, Sr, Rb, Cd, Sn and Ni increased from 1 to 3 times compared to the control. Bioaccumulation of metals/metalloids in the exposure water varied significantly between organs, with the muscle and liver showing the highest concentrations of metals, followed by the brain. Lipoperoxidation and malondialdehyde increased only in muscle, while carbonyl proteins increased only in the liver and brain. Regarding nitric oxide synthase, there was an increase in the liver and brain in the group exposed to SePM. Catalase activity decreased in the liver and muscle, while the activity of glutathione peroxidase, increased in the liver and kidney and decreased in muscle. Glutathione S-transferase, which is mainly responsible for detoxification, increased in the liver and decreased in muscle and the kidney. Cholinesterase activity increased only in the muscle. The results indicate oxidative stress, due to oxidation catalyzed by metals, components of SePM. Thus, the results contribute to the understanding that SePM has a deleterious effect on the aquatic environment, negatively affecting bullfrog tadpoles, in different ways and levels in relation to the analyzed organs.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Ltd.)
Databáze: MEDLINE
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