Sedative and cardiorespiratory effects of dexmedetomidine alone or combined with acepromazine in healthy cats.

Autor: Schimites PI; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil. Electronic address: paulaschimites.vet@gmail.com., Mangini LT; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil., Gasparotto JC; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil., Franco IG; University Center of Ourinhos, Ourinhos, São Paulo State, Brazil., Alves TS; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil., Biaggio ML; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil., Mangini NP; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil., Freitas GC; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil., Floriano BP; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil., Soares AV; Federal University of Santa Maria (UFSM), Post-Graduation Program in Veterinary Medicine, Center of Rural Sciences, Department of Small Animal Clinic, Santa Maria, Rio Grande do Sul State 97105-900, Brazil.
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2024 Apr; Vol. 304, pp. 106099. Date of Electronic Publication: 2024 Mar 08.
DOI: 10.1016/j.tvjl.2024.106099
Abstrakt: The purpose of this study was to assess sedation, emesis and cardiovascular effects of dexmedetomidine alone or combined with acepromazine in healthy cats. Fourteen male cats aged 0.9 ± 0.5 years and weighing 3.7 ± 0.7 kg were randomly assigned to one of two experimental groups: GD, dexmedetomidine 5 µg/kg; and GDA, dexmedetomidine 5 µg/kg with acepromazine 0.03 mg/kg, all intramuscularly. Measurements were recorded at baseline, at 20 minutes and then at 10-minute intervals following sedation and included heart rate (HR), respiratory rate (F R ), systolic arterial pressure (SAP), rectal temperature (RT), number of episodes of emesis and sedation score (0-4). Data were compared using ANOVA for repeated measures followed by Šídák and Dunnet test. Sedation scores were compared between groups at T20 using Mann-Whitney test. Significance was considered when P <0.05. At T20, HR was significantly lower in GDA (99 ± 14 beats/min) compared with GD (133 ± 19 beats/min) and SAP was significantly lower in both groups compared with baseline (126 ± 14 vs. 148 ± 26 and 111 ± 13 vs. 144 ± 17 mmHg in GD and GDA, respectively). Duration of sedation was similar between groups, although sedation scores differed significantly at T20, with 1 (0-4) in GD and 4 (4-4) in GDA. More episodes of emesis were recorded in GD compared with GDA. The combination of dexmedetomidine and acepromazine produced more profound sedation with faster onset and lower incidence of emesis compared with dexmedetomidine alone in healthy cats.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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