SPRY1 Deficiency in Keratinocytes Induces Follicular Melanocyte Stem Cell Migration to the Epidermis through p53/Stem Cell Factor/C-KIT Signaling.

Autor:	Cui YZ; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Xu F; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhou Y; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wang ZY; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Yang XY; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Fu NC; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen XB; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zheng YX; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen XY; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Ye LR; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Li YY; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Man XY; Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: manxy@zju.edu.cn.
Jazyk:	angličtina
Zdroj:	The Journal of investigative dermatology [J Invest Dermatol] 2024 Oct; Vol. 144 (10), pp. 2255-2266.e4. Date of Electronic Publication: 2024 Mar 08.
DOI:	10.1016/j.jid.2024.02.018
Abstrakt:	The function and survival of melanocytes is regulated by an elaborate network of paracrine factors synthesized mainly by epidermal keratinocytes (KCs). KCs and melanocytes respond to UV exposure by eliciting a tanning response. However, how KCs and melanocytes interact in the absence of UV exposure is unknown. In this study, we demonstrate that after SPRY1 knockout in epidermal KCs, melanocyte stem cells in the hair follicle exit the niche without depleting the pool of these cells. We also found that melanocyte stem cells migrate to the epidermis in a p53/stem cell factor/C-KIT-dependent manner induced by a tanning-like response resulting from SPRY1 loss in epidermal KCs. Once there, these cells differentiate into functional melanocytes. These findings provide an example in which the migration of melanocyte stem cells to the epidermis is due to loss of SPRY1 in epidermal KCs and show the potential for developing therapies for skin pigmentation disorders by manipulating melanocyte stem cells. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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