Distribution of maternal risk factors for orofacial cleft in infants in Indonesia: a multicenter prospective study.

Autor: Tajrin A; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia., Ruslin M; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia., Rasul MI; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia., Nurwahida; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia., Hadira; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia., Mubarak H; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia., Oginawati K; Department of Environmental Engineering, Faculty of Civil and Environmental Engineering, Institut Teknologi Bandung, Bandung, Indonesia., Fahimah N; Department of Environmental Engineering, Faculty of Civil and Environmental Engineering, Institut Teknologi Bandung, Bandung, Indonesia., Tanziha I; Department of Community Nutrition, Faculty of Human Ecology, Bogor Institute of Agriculture, Bogor, Indonesia., Damayanti AD; Department of Environmental Engineering, Faculty of Engineering, Hasanuddin University, Makassar, Indonesia., Mukhaiyar U; Statistics Research Division, Institut Teknologi Bandung, Bandung, Indonesia., Arumsari A; Departement Oral and Maxillofacial Surgery, RSUP Dr Hasan Sadikin, Faculty of Dentistry, Padjajaran University Bandung, Indonesia., Astuti IA; Department of Oral and Maxillofacial Surgery, Padjadjaran University, Bandung, Indonesia., Putri FA; Department of Oral and Maxillofacial Surgery, Padjadjaran University, Bandung, Indonesia., Silvia S; Department of Environmental Engineering, Faculty of Engineering, Andalas University, Padang, Indonesia.
Jazyk: angličtina
Zdroj: Archives of craniofacial surgery [Arch Craniofac Surg] 2024 Feb; Vol. 25 (1), pp. 11-16. Date of Electronic Publication: 2024 Feb 20.
DOI: 10.7181/acfs.2023.00521
Abstrakt: Background: The pathogenesis of orofacial cleft (OFC) is multifactorial, involving both genetic and non-genetic factors, the latter of which play a key role in the development of these anomalies. This paper addresses the incidence of OFC in Indonesia, with a focus on identifying and examining the distribution of contributory factors, including parental medical history, pregnancy history, and environmental influences.
Methods: The study was conducted through the collection of primary data. An interdisciplinary research team from Indonesia administered a standardized questionnaire to parents who had children with OFC and who had provided informed consent. The case group comprised 133 children born with cleft lip and/or palate, and the control was 133 noncleft children born full-term. The risk factors associated with OFC anomalies were analyzed using the chi-square test and logistic regression. All statistical analyses were performed using SPSS version 25. A p-value of 0.05 or less was considered to indicate statistical significance.
Results: The study comprised 138 children, of whom 82 were boys (59.4%) and 56 were girls (40.6%). Among them, 45 patients (32.6%) presented with both cleft lip and cleft palate, 25 individuals (18.1%) had a cleft palate only, and 28 patients (20.3%) had a cleft lip only. OFC was found to be significantly associated with a maternal family history of congenital birth defects (p< 0.05), complications during the first trimester (p< 0.05), consumption of local fish (p< 0.05), caffeine intake (p< 0.05), prolonged medication use (p< 0.05), immunization history (p< 0.05), passive smoking (p< 0.05), and X-ray exposure during pregnancy (p< 0.05).
Conclusion: The findings indicate close relationships between the incidence of OFC and maternal medical history, prenatal factors, and environmental influences.
Databáze: MEDLINE
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