A chemical magnet: Approaches to guide precise protein localization.

Autor: Kumar S; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Nabet B; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. Electronic address: bnabet@fredhutch.org.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Mar 15; Vol. 102, pp. 117672. Date of Electronic Publication: 2024 Mar 02.
DOI: 10.1016/j.bmc.2024.117672
Abstrakt: Small molecules that chemically induce proximity between two proteins have been widely used to precisely modulate protein levels, stability, and activity. Recently, several studies developed novel strategies that employ heterobifunctional molecules that co-opt shuttling proteins to control the spatial localization of a target protein, unlocking new potential within this domain. Together, these studies lay the groundwork for novel targeted protein relocalization modalities that can rewire the protein circuitry and interactome to influence biological outcomes.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: B.N. is an inventor on patent applications related to the dTAG system (WO/2017/024318, WO/2017/024319, WO/2018/148440, WO/2018/148443, and WO/2020/146250). The Nabet laboratory receives or has received research funding from Mitsubishi Tanabe Pharma America, Inc.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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