Granular retrosplenial cortex layer 2/3 generates high-frequency oscillations dynamically coupled with hippocampal rhythms across brain states.

Autor:	Arndt KC; School of Neuroscience, Virginia Tech, Blacksburg, VA 24060, USA., Gilbert ET; School of Neuroscience, Virginia Tech, Blacksburg, VA 24060, USA., Klaver LMF; School of Neuroscience, Virginia Tech, Blacksburg, VA 24060, USA., Kim J; The Bradley Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, VA 24060, USA., Buhler CM; School of Neuroscience, Virginia Tech, Blacksburg, VA 24060, USA., Basso JC; School of Neuroscience, Virginia Tech, Blacksburg, VA 24060, USA; Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA 24060, USA; Center for Health Behaviors Research, Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA, USA., McKenzie S; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA. Electronic address: samckenzie@salud.unm.edu., English DF; School of Neuroscience, Virginia Tech, Blacksburg, VA 24060, USA. Electronic address: neurodan83@vt.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Mar 26; Vol. 43 (3), pp. 113910. Date of Electronic Publication: 2024 Mar 08.
DOI:	10.1016/j.celrep.2024.113910
Abstrakt:	The granular retrosplenial cortex (gRSC) exhibits high-frequency oscillations (HFOs; ∼150 Hz), which can be driven by a hippocampus-subiculum pathway. How the cellular-synaptic and laminar organization of gRSC facilitates HFOs is unknown. Here, we probe gRSC HFO generation and coupling with hippocampal rhythms using focal optogenetics and silicon-probe recordings in behaving mice. ChR2-mediated excitation of CaMKII-expressing cells in L2/3 or L5 induces HFOs, but spontaneous HFOs are found only in L2/3, where HFO power is highest. HFOs couple to CA1 sharp wave-ripples (SPW-Rs) during rest and the descending phase of theta. gRSC HFO current sources and sinks are the same for events during both SPW-Rs and theta oscillations. Independent component analysis shows that high gamma (50-100 Hz) in CA1 stratum lacunosum moleculare is comodulated with HFO power. HFOs may thus facilitate interregional communication of a multisynaptic loop between the gRSC, hippocampus, and medial entorhinal cortex during distinct brain and behavioral states. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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