The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank.

Autor: Rodriguez-Ayllon M; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands., Neumann A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands., Hofman A; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands., Vernooij MW; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, the Netherlands. Electronic address: m.vernooij@erasmusmc.nl., Neitzel J; Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, the Netherlands; Department of Epidemiology, Harvard T.H Chan School of Public Health, Boston, MA, United States.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2024 Jun; Vol. 138, pp. 1-9. Date of Electronic Publication: 2024 Mar 04.
DOI: 10.1016/j.neurobiolaging.2024.03.001
Abstrakt: Physical activity is a protective factor against brain atrophy, while loss of brain volume could also be a determinant of physical activity. Therefore, we aimed to explore the bidirectional association of physical activity with brain structures in middle-aged and older adults from the UK Biobank. Overall, 3027 participants (62.45 ± 7.27 years old, 51.3% females) had data at two time points. Hippocampal volume was associated with total (β=0.048, p FDR =0.016) and household (β=0.075, p FDR <0.001) physical activity. Global fractional anisotropy (β=0.042, p FDR =0.028) was also associated with household physical activity. In the opposite direction, walking was negatively associated with white matter volume (β=-0.026, p FDR =0.008). All these associations were confirmed by the linear mixed models. Interestingly, sports at baseline were linked to hippocampal and frontal cortex volumes at follow-up but these associations disappeared after adjusting for multiple comparisons (p all >0.104). In conclusion, we found more consistent evidence that a healthier brain structure predicted higher physical activity levels than for the inverse, more established relationship.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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