Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years.

Autor: Huang LJ; College of Rehabilitation, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Lan JX; College of Public Health and Health Management, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Wang JH; Ji'an Central People's Hospital (Shanghai East Hospital Ji'an Hospital), Ji'an, Jiangxi 343100, PR China., Huang H; College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Lu K; Henan International Joint Laboratory of Children's Infectious Diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan 450018, PR China., Zhou ZN; College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Xin SY; College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Zhang ZY; College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Wang JY; College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Dai P; College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China., Chen XM; Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, PR China., Hou W; College of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000, PR China. Electronic address: twenhou@gmu.edu.cn.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Apr; Vol. 173, pp. 116406. Date of Electronic Publication: 2024 Mar 08.
DOI: 10.1016/j.biopha.2024.116406
Abstrakt: Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to possess broad-spectrum biological activities, such as antitumor, anti-inflammatory, antiosteoporosis, neuroprotective, and antipathogenic microorganism activities. In this paper, recent progress on the biological activity and mechanism of action of sanguinarine and its derivatives over the past ten years is reviewed. The results showed that the biological activities of hematarginine and its derivatives are related mainly to the JAK/STAT, PI3K/Akt/mTOR, NF-κB, TGF-β, MAPK and Wnt/β-catenin signaling pathways. The limitations of using sanguinarine in clinical application are also discussed, and the research prospects of this subject are outlined. In general, sanguinarine, a natural medicine, has many pharmacological effects, but its toxicity and safety in clinical application still need to be further studied. This review provides useful information for the development of sanguinarine-based bioactive agents.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: