A 15% Trichloroacetic Acid + 3% Glycolic Acid Chemical Peel Series Improves Appearance of Hand Lentigines: An Evaluator-Blinded, Split-Hand Prospective Trial.

Autor:	Alajmi A; Main Line Center for Laser Surgery, Ardmore, Pennsylvania., Niaz G; Main Line Center for Laser Surgery, Ardmore, Pennsylvania.; King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia., Chen C; Department of Dermatology, Temple University, Philadelphia, Pennsylvania., Lee K; Main Line Center for Laser Surgery, Ardmore, Pennsylvania.; Department of Dermatology, Temple University, Philadelphia, Pennsylvania.
Jazyk:	angličtina
Zdroj:	Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2024 May 01; Vol. 50 (5), pp. 467-470. Date of Electronic Publication: 2024 Mar 08.
DOI:	10.1097/DSS.0000000000004114
Abstrakt:	Background: Improving the appearance of lentigines on the hands is a key component to hand rejuvenation. Soft tissue fillers revolumize hands, but do not address pigmentary changes. OBJECTIVE: This study investigated the effiacy of a 15% trichloroacetic acid (TCA) + 3% glycolic acid (GA) combination peel in improvement of appearance of hand lentigines. Methods: A prospective evaluator-blinded, split-hand study was performed using a 15% TCA + 3% GA peel to treat patients with hand lentigines. Subjects received a total of 3 treatments at 4-week intervals on 1 hand, with the other hand serving as an untreated control. Final photographs were taken 12 weeks after the last treatment. Two blinded board-certified dermatologists graded improvement in hand lentigines using a 5-point scale. Results: Eighteen of 20 patients completed the study (90%). The mean age was 64.4 years (SE 1.6, range 51-71). The mean pain scores were 3.8 (SE 0.4) on a 10-point scale (1 = no pain, 10 = extremely painful). Blinded evaluators correctly identified the after-treatment photographs in 16 patients (88%). Physician and patient-graded mean improvement of lentigines was significant for treated versus control hands ( p < .01). No adverse events were noted. Conclusion: A series of three 15% TCA + 3% GA peels are effective and safe in the treatment of hand lentigines. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Society for Dermatologic Surgery, Inc.)
Databáze:	MEDLINE
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