Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation.

Autor: Furtado LV; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Cardenas M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Santiago T; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Ruiz RE; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Shi Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Pappo A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Kacar M; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Jazyk: angličtina
Zdroj: Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2024 Mar; Vol. 63 (3), pp. e23230.
DOI: 10.1002/gcc.23230
Abstrakt: Childhood melanoma is a rare and biologically heterogeneous pediatric malignancy. The differential diagnosis of pediatric melanoma is usually broad, including a wide variety of spindle cell or epithelioid neoplasms. Different molecular alterations affecting the MAPK and PI3K/AKT/mTOR pathways, tumor suppressor genes, and telomerase reactivation have been implicated in melanoma tumorigenesis and progression. Here, we report a novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and an aggressive clinical course.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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