Iatrogenic myelodysplastic syndrome complicating multiple sclerosis: A case report.
| Autor: | Kubicki K; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Stefoski D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2024 Mar 08, pp. 13524585241235539. Date of Electronic Publication: 2024 Mar 08. |
| DOI: | 10.1177/13524585241235539 |
| Abstrakt: | After 1.5 years of treatment with dimethyl fumarate (DMF) for multiple sclerosis, preceded 8 years earlier by intravenous (IV) cladribine and 1 year earlier by natalizumab, our patient developed myelodysplastic syndrome (MDS). The initial manifestation was a severe drop in absolute neutrophil and lymphocyte counts. Repeat bone marrow biopsy demonstrated a new unbalanced translocation (between the chromosome 1 long arm and chromosome 7 short arm). This case report, to our knowledge, is the first linking iatrogenic MDS to DMF and cladribine, while also suggesting caution with immunosuppressants in multiple sclerosis patients. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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