Role of IL-18 in adipose tissue remodeling and metabolic dysfunction.

Autor: Lana JP; Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., de Oliveira MC; Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Silveira ALM; Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Yamada LTP; Faculty of Nutrition, Universidade Federal de Alfenas, Alfenas, Brazil., Costa KA; Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., da Silva SV; Department of Cellular Biology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., de Assis-Ferreira A; Department of Cellular Biology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Gautier EL; Sorbonne Université, INSERM, UMRS 1166, F-75013, Paris, France., Dussaud S; Sorbonne Université, INSERM, UMRS 1166, F-75013, Paris, France., Pinho V; Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Teixeira MM; Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Marcelin G; Sorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, Nutriomics, Research Unit, F-75013, Paris, France.; Assistance Publique Hôpitaux de Paris, APHP, Nutrition Department, Pitié-Salpêtrière Hospital, F-75013, Paris, France., Clément K; Sorbonne Université, Inserm, Nutrition and Obesities: Systemic Approaches, Nutriomics, Research Unit, F-75013, Paris, France.; Assistance Publique Hôpitaux de Paris, APHP, Nutrition Department, Pitié-Salpêtrière Hospital, F-75013, Paris, France., Ferreira AVM; Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. adaliene@gmail.com.
Jazyk: angličtina
Zdroj: International journal of obesity (2005) [Int J Obes (Lond)] 2024 Jul; Vol. 48 (7), pp. 964-972. Date of Electronic Publication: 2024 Mar 08.
DOI: 10.1038/s41366-024-01507-5
Abstrakt: Background/objectives: Proinflammatory cytokines are increased in obese adipose tissue, including inflammasome key masters. Conversely, IL-18 protects against obesity and metabolic dysfunction. We focused on the IL-18 effect in controlling adipose tissue remodeling and metabolism.
Materials/subjects and Methods: We used C57BL/6 wild-type (WT) and interleukine-18 deficient (IL-18 -/- ) male mice fed a chow diet and samples from bariatric surgery patients.
Results: IL-18 -/- mice showed increased adiposity and proinflammatory cytokine levels in adipose tissue, leading to glucose intolerance. IL-18 was widely secreted by stromal vascular fraction but not adipocytes from mice's fatty tissue. Chimeric model experiments indicated that IL-18 controls adipose tissue expansion through its presence in tissues other than bone marrow. However, IL-18 maintains glucose homeostasis when present in bone marrow cells. In humans with obesity, IL-18 expression in omental tissue was not correlated with BMI or body fat mass but negatively correlated with IRS1, GLUT-4, adiponectin, and PPARy expression. Also, the IL-18RAP receptor was negatively correlated with IL-18 expression.
Conclusions: IL-18 signaling may control adipose tissue expansion and glucose metabolism, as its absence leads to spontaneous obesity and glucose intolerance in mice. We suggest that resistance to IL-18 signaling may be linked with worse glucose metabolism in humans with obesity.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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