Chitin nanocrystals/alginate complex for tuning stability, rheology and bioavailability of cholecalciferol in Pickering emulsions.

Autor: Torlopov MA; Institute of Chemistry of Federal Research Centre 'Komi Science Centre of the Ural Branch of Russian Academy of Sciences', 48 Pervomayskaya St., 167000 Syktyvkar, Russian Federation., Vaseneva IN; Institute of Chemistry of Federal Research Centre 'Komi Science Centre of the Ural Branch of Russian Academy of Sciences', 48 Pervomayskaya St., 167000 Syktyvkar, Russian Federation., Mikhaylov VI; Institute of Chemistry of Federal Research Centre 'Komi Science Centre of the Ural Branch of Russian Academy of Sciences', 48 Pervomayskaya St., 167000 Syktyvkar, Russian Federation., Martakov IS; Institute of Chemistry of Federal Research Centre 'Komi Science Centre of the Ural Branch of Russian Academy of Sciences', 48 Pervomayskaya St., 167000 Syktyvkar, Russian Federation. Electronic address: gmartakov@gmail.com., Legki PV; Institute of Chemistry of Federal Research Centre 'Komi Science Centre of the Ural Branch of Russian Academy of Sciences', 48 Pervomayskaya St., 167000 Syktyvkar, Russian Federation; Federal State Budgetary Educational Institution of Higher Education «Pitirim Sorokin Syktyvkar State University», 55 Oktyabrskiy Av., 167000 Syktyvkar, Russian Federation., Sitnikov PA; Institute of Chemistry of Federal Research Centre 'Komi Science Centre of the Ural Branch of Russian Academy of Sciences', 48 Pervomayskaya St., 167000 Syktyvkar, Russian Federation.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Apr; Vol. 264 (Pt 2), pp. 130671. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1016/j.ijbiomac.2024.130671
Abstrakt: In this paper we investigate polyelectrolyte complexes of sodium alginate (Alg) and chitin nanocrystals (ChNC). Formation, stability and transport properties of sunflower oil-in-water emulsions stabilized by ChNC-Alg complex were studied using dynamic light scattering (DLS), laser Doppler electrophoresis, optical microscopy, potentiometric titration, rheology and simulated digestion. It has been established that during emulsions formation, the ChNC-Alg complex is rearranged at the interface and the formation of a two-layer coating of the droplet occurs. Stabilized O/W emulsions are stable during storage, in the pH range 2-9 and centrifugal acceleration up to 2000 RCF. Presence of Ca 2+ and Na + ions in the range up to 150 mM has virtually no effect on the droplet size. Inclusion of 5 wt% Alg in the ChNC-based emulsion stabilizer system leads to a drop in Gibbs adsorption >16 times compared to the ChNC-stabilized emulsion, increase in viscosity and rheopexy index of the systems. We found that chemical properties of colloidal phase surface and rheological properties of emulsions stabilized by ChNC-Alg are mostly dependent on the droplet size, not the type of oil as a result of a comparative study of sunflower oil/liquid paraffin oil. Emulsion drops of an optimized composition are stable in the upper parts of the model gastrointestinal tract system and transport vitamin D3 to the small intestine without significant losses. The bioavailability of vitamin D3 in emulsions stabilized with the ChNC-Alg complex is higher than for emulsions stabilized with ChNC alone.
Competing Interests: Declaration of competing interest We confirm that there are no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: