Prevalence of infectious diseases, immunity to vaccine-preventable diseases and chronic medical conditions among Ukrainian refugees in Germany - A cross sectional study from the German Network University Medicine (NUM).

Autor:	Brinkmann F; University Children's Hospital, Katholisches Klinikum Bochum, Ruhr-University Bochum, Bochum, Germany., Friedrichs A; Department of Internal Medicine I, Infectious Diseases, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Behrens GM; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Site Hannover-Braunschweig, Hannover, Germany., Behrens P; Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany., Berner R; Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Caliebe A; Institute of Medical Informatics and Statistics, Kiel University and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Denkinger CM; Division of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany; German Centre for Infection Research, partner site Heidelberg, Germany., Giesbrecht K; Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany., Gussew A; Clinic and Policlinic of Radiology, University Medical Clinic Halle, Halle (Saale), Germany., Hoffmann AT; University Children's Hospital, Katholisches Klinikum Bochum, Ruhr-University Bochum, Bochum, Germany., Hojenski L; Department of Internal Medicine I, Infectious Diseases, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Hovardovska O; Department of Epidemiology, Helmholtz Centre for Infection Research Braunschweig, Germany; German Centre for Infection Research, TI BBD, Helmholtz Centre for Infection Research, Braunschweig, Germany., Dopfer-Jablonka A; Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Site Hannover-Braunschweig, Hannover, Germany., Kaasch AJ; Institute of Medical Microbiology and Hospital Hygiene, Faculty of Medicine, Otto-von-Guericke-University Magdeburg., Kobbe R; Institute for Infection Research and Vaccine Development (IIRVD), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany; Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany., Kraus M; Institute of Epidemiology, Helmholtz Zentrum München, Munich, Germany., Lindner A; Charité - Universitätsmedizin Berlin, Charité Center for Global Health, Institute of International Health, Berlin, Germany., Maier C; University Children's Hospital, Katholisches Klinikum Bochum, Ruhr-University Bochum, Bochum, Germany., Mitrov L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Germany., Nauck M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine of Greifswald, Greifswald, Germany; DZHK (German Centre for Cardiovacsular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany., de Miranda SN; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Germany., Scherer M; Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Hematology/Oncology, Frankfurt am Main, Germany., Schmiedel Y; Department of Internal Medicine I, Infectious Diseases, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Stahl D; Trusted Third Party of the University Medicine Greifswald, Greifswald, Germany., Timmesfeld N; Department of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Germany., Toepfner N; Department of Pediatrics, Faculty of Medicine and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany., Vehreschild J; DZHK (German Centre for Cardiovacsular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany., Wohlgemuth WA; Clinic and Policlinic of Radiology, University Medical Clinic Halle, Halle (Saale), Germany., Petersmann A; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine of Greifswald, Greifswald, Germany; Institute for Clinical Chemistry and Laboratory Medicine, University Medicine Oldenburg, Oldenburg, Germany., Vehreschild MJGT; Goethe University Frankfurt, University Hospital Frankfurt, Department of Internal Medicine, Infectious Diseases, Frankfurt am Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany. Electronic address: vehreschild@med.uni-frankfurt.de.
Jazyk:	angličtina
Zdroj:	Journal of infection and public health [J Infect Public Health] 2024 Apr; Vol. 17 (4), pp. 642-649. Date of Electronic Publication: 2024 Feb 16.
DOI:	10.1016/j.jiph.2024.02.003
Abstrakt:	Background: Vulnerability to infectious diseases in refugees is dependent on country of origin, flight routes, and conditions. Information on specific medical needs of different groups of refugees is lacking. We assessed the prevalence of infectious diseases, immunity to vaccine-preventable diseases, and chronic medical conditions in children, adolescents, and adult refugees from Ukraine who arrived in Germany in 2022. Methods: Using different media, we recruited Ukrainian refugees at 13 sites between 9-12/2022. An antigen test for acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, serologies for a range of vaccine-preventable diseases, as well as interferon gamma release assays (IGRAs) for tuberculosis (TB), and SARS-CoV-2 were performed. We assessed personal and family history of chronic medical conditions, infectious diseases, vaccination status, and conditions during migration. Results: Overall, 1793 refugees (1401 adults and 392 children/adolescents) were included. Most participants were females (n = 1307; 72·3%) and from Eastern or Southern Ukraine. TB IGRA was positive in 13% (n = 184) of the adults and in 2% (n = 7) of the children. Serology-based immunological response was insufficient in approximately 21% (360/1793) of the participants for measles, 32% (572/1793) for diphtheria, and 74% (1289/1793) for hepatitis B. Conclusions: We show evidence of low serological response to vaccine-preventable infections and increased LTBI prevalence in Ukrainian refugees. These findings should be integrated into guidelines for screening and treatment of infectious diseases in migrants and refugees in Germany and Europe. Furthermore, low immunity for vaccine-preventable diseases in Ukrainians independent of their refugee status, calls for tailor-made communication efforts. Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest. (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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