The metabolic domestication syndrome of budding yeast.

Autor:	Tengölics R; Hungarian Centre of Excellence for Molecular Medicine - Biological Research Centre Metabolic Systems Biology Lab, Szeged 6726, Hungary.; Synthetic and System Biology Unit, National Laboratory of Biotechnology, Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary.; Metabolomics Lab, Core facilities, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary., Szappanos B; Hungarian Centre of Excellence for Molecular Medicine - Biological Research Centre Metabolic Systems Biology Lab, Szeged 6726, Hungary.; Synthetic and System Biology Unit, National Laboratory of Biotechnology, Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary.; Department of Biotechnology, University of Szeged, Szeged 6726, Hungary., Mülleder M; Charité Universitätsmedizin, Core Facility High-Throughput Mass Spectrometry, Berlin 10117, Germany., Kalapis D; Hungarian Centre of Excellence for Molecular Medicine - Biological Research Centre Metabolic Systems Biology Lab, Szeged 6726, Hungary.; Synthetic and System Biology Unit, National Laboratory of Biotechnology, Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary., Grézal G; Hungarian Centre of Excellence for Molecular Medicine - Biological Research Centre Metabolic Systems Biology Lab, Szeged 6726, Hungary.; Synthetic and System Biology Unit, National Laboratory of Biotechnology, Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary., Sajben C; Metabolomics Lab, Core facilities, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary., Agostini F; Department of Biochemistry, Charité Universitätsmedizin, Berlin 10117, Germany., Mokochinski JB; Synthetic and System Biology Unit, National Laboratory of Biotechnology, Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary., Bálint B; Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary., Nagy LG; Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary., Ralser M; Department of Biochemistry, Charité Universitätsmedizin, Berlin 10117, Germany.; The Francis Crick Institute, Molecular Biology of Metabolism Laboratory, London NW11AT, United Kingdom., Papp B; Hungarian Centre of Excellence for Molecular Medicine - Biological Research Centre Metabolic Systems Biology Lab, Szeged 6726, Hungary.; Synthetic and System Biology Unit, National Laboratory of Biotechnology, Institute of Biochemistry, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary.; National Laboratory for Health Security, Biological Research Centre, Hungarian Research Network, Szeged 6726, Hungary.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 12; Vol. 121 (11), pp. e2313354121. Date of Electronic Publication: 2024 Mar 08.
DOI:	10.1073/pnas.2313354121
Abstrakt:	Cellular metabolism evolves through changes in the structure and quantitative states of metabolic networks. Here, we explore the evolutionary dynamics of metabolic states by focusing on the collection of metabolite levels, the metabolome, which captures key aspects of cellular physiology. Using a phylogenetic framework, we profiled metabolites in 27 populations of nine budding yeast species, providing a graduated view of metabolic variation across multiple evolutionary time scales. Metabolite levels evolve more rapidly and independently of changes in the metabolic network's structure, providing complementary information to enzyme repertoire. Although metabolome variation accumulates mainly gradually over time, it is profoundly affected by domestication. We found pervasive signatures of convergent evolution in the metabolomes of independently domesticated clades of Saccharomyces cerevisiae . Such recurring metabolite differences between wild and domesticated populations affect a substantial part of the metabolome, including rewiring of the TCA cycle and several amino acids that influence aroma production, likely reflecting adaptation to human niches. Overall, our work reveals previously unrecognized diversity in central metabolism and the pervasive influence of human-driven selection on metabolite levels in yeasts. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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