A preliminary investigation into cortical structural alterations in adolescents with nonsuicidal self-injury.

Autor: Patel KK; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sheridan MA; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bonar AS; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Giletta M; Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium.; Department of Developmental Psychology, Tilburg University, Tilburg, Netherlands., Hastings PD; Department of Psychology, University of California, Davis, Davis, CA, USA., Nock MK; Department of Psychology, Harvard University, Cambridge, MA, USA., Rudolph KD; Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USA., Slavich GM; Cousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA., Prinstein MJ; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Miller AB; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; RTI International, Research Triangle Park, NC, USA.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2023 Dec; Vol. 336. Date of Electronic Publication: 2023 Oct 20.
DOI: 10.1016/j.pscychresns.2023.111725
Abstrakt: The structural neural correlates underlying youth nonsuicidal self-injury (NSSI) warrant further exploration. Few studies have explored the association between NSSI and brain structure in adolescence, and no studies have investigated differences in the relation between age and brain structure in youth with NSSI. This preliminary investigation examined associations between NSSI history, age, and cortical structure using magnetic resonance imaging in adolescent girls ( N =100, M age =13.4 years) at increased risk for psychopathology. We conducted whole-brain analyses to investigate the associations between age and cortical structure, NSSI history and cortical structure, and NSSI history as a moderator of the association between age and cortical structure. Results suggested that age was associated with less cortical thickness and surface area in the left and right prefrontal, temporal, and parietal cortex. NSSI history was associated with less left insula and left inferior parietal cortex cortical surface area. Among adolescents with NSSI history, older age predicted greater left inferior parietal cortex surface area and was not associated with left precentral cortex surface area. Among adolescents without NSSI history, older age predicted smaller surface areas as expected with the typical trajectory of neurodevelopment. Overall, our results suggest differences in cortical surface area development in adolescents with NSSI history.
Competing Interests: Declaration of Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Databáze: MEDLINE
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