Attrition in the Gothenburg H70 birth cohort studies, an 18-year follow-up of the 1930 cohort.

Autor:	Rydén L; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Wetterberg H; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Ahlner F; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Falk Erhag H; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Gudmundsson P; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Guo X; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Department of Mood Disorders, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Joas E; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Johansson L; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Kern S; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Psychiatry, Cognition and Old Age Psychiatry Clinic, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Mellqvist Fässberg M; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Najar J; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Psychiatry, Cognition and Old Age Psychiatry Clinic, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Ribbe M; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Rydberg Sterner T; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden., Sacuiu S; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Psychiatry, Cognition and Old Age Psychiatry Clinic, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Samuelsson J; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Sigström R; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Psychiatry, Cognition and Old Age Psychiatry Clinic, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Skoog J; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Waern M; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Region Västra Götaland, Department of Psychiatry, Psychotic Disorders, Sahlgrenska University Hospital, Mölndal, Sweden., Zettergren A; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden., Skoog I; Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden.; Psychiatry, Cognition and Old Age Psychiatry Clinic, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden.
Jazyk:	angličtina
Zdroj:	Frontiers in epidemiology [Front Epidemiol] 2023 May 09; Vol. 3, pp. 1151519. Date of Electronic Publication: 2023 May 09 (Print Publication: 2023).
DOI:	10.3389/fepid.2023.1151519
Abstrakt:	Background: Longitudinal studies are essential to understand the ageing process, and risk factors and consequences for disorders, but attrition may cause selection bias and impact generalizability. We describe the 1930 cohort of the Gothenburg H70 Birth Cohort Studies, followed from age 70 to 88, and compare baseline characteristics for those who continue participation with those who die, refuse, and drop out for any reason during follow-up. Methods: A population-based sample born 1930 was examined with comprehensive assessments at age 70 ( N  = 524). The sample was followed up and extended to increase sample size at age 75 ( N  = 767). Subsequent follow-ups were conducted at ages 79, 85, and 88. Logistic regression was used to analyze baseline characteristics in relation to participation status at follow-up. Results: Refusal to participate in subsequent examinations was related to lower educational level, higher blood pressure, and lower scores on cognitive tests. Both attrition due to death and total attrition were associated with male sex, lower educational level, smoking, ADL dependency, several diseases, poorer lung function, slower gait speed, lower scores on cognitive tests, depressive symptoms, and a larger number of medications. Attrition due to death was also associated with not having a partner. Conclusions: It is important to consider different types of attrition when interpreting results from longitudinal studies, as representativeness and results may be differently affected by different types of attrition. Besides reducing barriers to participation, methods such as imputation and weighted analyses can be used to handle selection bias. Competing Interests: SK has served at scientific advisory boards and/or as consultant for Geras Solutions and Biogen. EJ is currently employed at IQVIA, SE-431 44, Mölndal, Sweden. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2023 Rydén, Wetterberg, Ahlner, Falk Erhag, Gudmundsson, Guo, Joas, Johansson, Kern, Mellqvist Fässberg, Najar, Ribbe, Rydberg Sterner, Sacuiu, Samuelsson, Sigström, Skoog, Waern, Zettergren and Skoog.)
Databáze:	MEDLINE
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