Plasma interleukin 6 as an outcome predictor of traumatic brain injury patients.

Autor:	Ichwan K; Department of Neurology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.; Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia., Gazali S; Department of Neurology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.; Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia., Suherman S; Department of Neurology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.; Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia., Desiana D; Department of Clinical Pathology, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.; Department of Clinical Pathology, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia., Nurjannah N; Department of Public Health, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Jazyk:	angličtina
Zdroj:	Narra J [Narra J] 2023 Dec; Vol. 3 (3), pp. e234. Date of Electronic Publication: 2023 Oct 18.
DOI:	10.52225/narra.v3i3.234
Abstrakt:	Traumatic brain injury is one of the leading causes of death and disability in young adults. Previous studies have suggested that neuroinflammatory process involves the overexpression of interleukin 6 (IL-6); however, data on the predictive ability of IL-6 is limited and conflicting in traumatic head injury patients. The aim of this study was to assess the ability of plasma IL-6 as a predictor of outcome in head injury patients. A cross-sectional study was conducted between June and December 2020 among traumatic head injury patients admitted to Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. Demographic, clinical data, and IL-6 level were collected and measured on admission. The outcome was assessed by the Glasgow outcome scale extended (GOSE) in the first- and third-month of post-injury. A total of 50 traumatic brain injury patients were recruited of which 54% were male, 64% had mild head injury, 82% had leukocytosis, and 60% had non-bleeding head CT scan. The mean of IL-6 level was 79.32 pg/mL while the GOSE scores ranged from 1 (death) to 8 (upper good recovery). Early IL-6 level (<24 hours post-injury) was significantly correlated with worse outcome in traumatic head injury, though the correlation strength was moderate ( p <0.001; r =-0.42). As a predictor, IL-6 yielded the area under curve (AUC) value of 93.5% ( p <0.001) and a cut-off point of 46.33 pg/mL. The sensitivity and specificity of this predictor were 87.5% and 95.24%, respectively. In conclusion, early IL-6 level can be used as a predictor for traumatic head injury. Nevertheless, further multi-center study with a bigger sample size is needed to confirm this finding. Competing Interests: The authors declare that there is no conflict of interest. (© 2023 The Author(s).)
Databáze:	MEDLINE
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