Folate-producing bifidobacteria: metabolism, genetics, and relevance.

Autor: D'Aimmo MR; BioGaia AB, Bioventure Hub, HE424, c/o AstraZeneca AB, R&D, Mölndal 43150, Sweden., Satti M; Department of Agricultural and Food Sciences, University of Bologna, Bologna 40127, Italy., Scarafile D; Department of Agricultural and Food Sciences, University of Bologna, Bologna 40127, Italy., Modesto M; Department of Agricultural and Food Sciences, University of Bologna, Bologna 40127, Italy., Pascarelli S; Protein Engineering and Evolution Unit, Okinawa Institute of Science, Technology Graduate University, Okinawa 40-0193, Japan., Biagini SA; Institut de Biologia Evolutiva (UPF-CSIC), Departament de Medicina i Ciències de la Vida, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona 08003, Spain., Luiselli D; Department for the Cultural Heritage (DBC), University of Bologna, Ravenna 48121, Italy., Mattarelli P; Department of Agricultural and Food Sciences, University of Bologna, Bologna 40127, Italy., Andlid T; Andlid Bio Solutions AB, Gothenburg 41871, Sweden.
Jazyk: angličtina
Zdroj: Microbiome research reports [Microbiome Res Rep] 2023 Dec 12; Vol. 3 (1), pp. 11. Date of Electronic Publication: 2023 Dec 12 (Print Publication: 2024).
DOI: 10.20517/mrr.2023.59
Abstrakt: Folate (the general term for all bioactive forms of vitamin B 9 ) plays a crucial role in the evolutionary highly conserved one-carbon (1C) metabolism, a network including central reactions such as DNA and protein synthesis and methylation of macromolecules. Folate delivers 1C units, such as methyl and formyl, between reactants. Plants, algae, fungi, and many bacteria can naturally produce folate, whereas animals, including humans, must obtain folate from external sources. For humans, folate deficiency is, however, a widespread problem. Bifidobacteria constitute an important component of human and many animal microbiomes, providing various health advantages to the host, such as producing folate. This review focuses on bifidobacteria and folate metabolism and the current knowledge of the distribution of genes needed for complete folate biosynthesis across different bifidobacterial species. Biotechnologies based on folate-trophic probiotics aim to create fermented products enriched with folate or design probiotic supplements that can synthesize folate in the colon, improving overall health. Therefore, bifidobacteria (alone or in association with other microorganisms) may, in the future, contribute to reducing widespread folate deficiencies prevalent among vulnerable human population groups, such as older people, women at child-birth age, and people in low-income countries.
Competing Interests: All authors declared that there are no conflicts of interest.
(© The Author(s) 2023.)
Databáze: MEDLINE
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