Synthesis and pharmacological activity of vinpocetine derivatives.

Autor:	Dong ZC; College of Pharmacy, Guizhou University of Traditional Chinese Medicine Guiyang 550025 China bwpan1105@163.com yingzhou71@126.com., Shi Y; College of Pharmacy, Guizhou University of Traditional Chinese Medicine Guiyang 550025 China bwpan1105@163.com yingzhou71@126.com., Liu LJ; College of Pharmacy, Guizhou University of Traditional Chinese Medicine Guiyang 550025 China bwpan1105@163.com yingzhou71@126.com., Feng TT; College of Pharmacy, Guizhou University of Traditional Chinese Medicine Guiyang 550025 China bwpan1105@163.com yingzhou71@126.com., Zhou Y; College of Pharmacy, Guizhou University of Traditional Chinese Medicine Guiyang 550025 China bwpan1105@163.com yingzhou71@126.com., Pan BW; College of Pharmacy, Guizhou University of Traditional Chinese Medicine Guiyang 550025 China bwpan1105@163.com yingzhou71@126.com.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2024 Mar 07; Vol. 14 (12), pp. 7981-7991. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).
DOI:	10.1039/d3ra07325d
Abstrakt:	Vinpocetine and its derivatives were extensively employed in the treatment of ischemic stroke, serving as effective cerebrovascular vasodilators. They could also be utilized for neuroprotection, anti-inflammatory purposes, anti-aging interventions, insomnia treatment, and antidepressant effects. However, due to issues such as hepatic first-pass effect, low bioavailability, and poor patient compliance with multiple dosing, the secondary development of Vinpocetine to address these limitations became a prominent area of research. Five primary methodologies were employed for the synthesis of Vinpocetine derivatives. These included substitution on the A ring to modify the 14-ester group, alteration of the 16-ethyl group, simplification of the D and E rings, and modification of the conformation of Vinpocetine. This paper summarized the current synthesis and activity studies of Vinpocetine and its derivatives, with the aim of providing a reference for the discovery of more potent derivatives of Vinpocetine. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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