Does stress response axis activation differ between patients with autoimmune disease and healthy people?

Autor: Montero-López E; Department of Evolutionary Psychology, University of Granada, Granada, Spain., Peralta-Ramírez MI; Department of Personality, Evaluation, and Psychological Treatment, University of Granada, Granada, Spain.; Mind, Brain and Behavior Research Center (CIMCYC), Granada, Spain., Ortego-Centeno N; Department of Medicine, University of Granada, Granada, Spain.; Systemic Autoimmune Diseases Unit, San Cecilio Clinical Hospital, Granada, Spain.; Biohealth Research Institute (IBS), Granada, Spain., Sabio JM; Systemic Autoimmune Disease Unit, Internal Medicine Service, Virgen de las Nieves University Hospital, Granada, Spain., Callejas-Rubio JL; Systemic Autoimmune Diseases Unit, San Cecilio Clinical Hospital, Granada, Spain.; Biohealth Research Institute (IBS), Granada, Spain., Navarrete-Navarrete N; Systemic Autoimmune Disease Unit, Internal Medicine Service, Virgen de las Nieves University Hospital, Granada, Spain., García-Ríos MC; Department of Physical Therapy, Faculty of Health Sciences, University of Granada, Granada, Spain., Santos-Ruiz A; Department of Health Psychology, School of Health Sciences, University of Alicante, Alicante, Spain.; Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain.
Jazyk: angličtina
Zdroj: Stress and health : journal of the International Society for the Investigation of Stress [Stress Health] 2024 Aug; Vol. 40 (4), pp. e3392. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1002/smi.3392
Abstrakt: Many studies have shown that patients with autoimmune disease present a hypoactive hypothalamic-pituitary-adrenal (HPA) axis, but the results are controversial. Our objective was to study differences in stress response axis activity between patients with autoimmune disease and healthy people. The study sample consisted of 97 women divided into four groups: 37 healthy women (HW), 21 with systemic lupus erythematosus (SLE), 21 with Sjögren's syndrome (SS), and 18 with systemic sclerosis (SSc). After being exposed to a stress task, participants' skin conductance and salivary cortisol levels were measured in order to assess their response to psychological stress. Diurnal cortisol concentrations were assessed by measuring salivary cortisol in samples collected five times over one day. In addition, self-administered questionnaires were used to assess psychological variables. A time × group interaction effect was found (p = 0.003) in salivary cortisol secretion in response to stressful challenge. The healthy group presented normal activation, the SS and SLE groups showed no activation, and the SSc group presented a similar activation pattern to the HW group, except at the time of recovery. Total cortisol production (AUCg) was higher in the SSc group than in the HW group (p = 0.001). Differences were also observed in the cortisol AUCg collected over one day between healthy women and patients with SLE (p = 0.004) as well as with SSc (p = 0.001): women with SLE and SSc presented higher total hormone production than healthy women. Patients with autoimmune disease present a different HPA axis response, which may contribute to the harmful effects of stress in these diseases.
(© 2024 The Authors. Stress and Health published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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