Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis.

Autor: Ji XT; School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China.; School of Medicine, Chongqing University, Chongqing, 400030, China., Yu WL; School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China.; Department of Stomatology, Huzhou Wuxing District People's Hospital, Huzhou Wuxing District Maternal and Child Health Hospital, Huzhou, 313008, China., Jin MJ; School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China.; School of Pharmacy, Zhejiang University, Hangzhou, 310030, China., Lu LJ; School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China.; Department of Stomatology, Haining Hospital of Traditional Chinese Medicine, Jiaxing, 314400, China., Yin HP; School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China., Wang HH; School of Basic Medical Sciences, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China. huanval@hznu.edu.cn.
Jazyk: angličtina
Zdroj: Current medical science [Curr Med Sci] 2024 Apr; Vol. 44 (2), pp. 281-290. Date of Electronic Publication: 2024 Mar 08.
DOI: 10.1007/s11596-024-2843-9
Abstrakt: Recent studies have shown that cellular levels of polyamines (PAs) are significantly altered in neurodegenerative diseases. Evidence from in vivo animal and in vitro cell experiments suggests that the cellular levels of various PAs may play important roles in the central nervous system through the regulation of oxidative stress, mitochondrial metabolism, cellular immunity, and ion channel functions. Dysfunction of PA metabolism related enzymes also contributes to neuronal injury and cognitive impairment in many neurodegenerative diseases. Therefore, in the current work, evidence was collected to determine the possible associations between cellular levels of PAs, and related enzymes and the development of several neurodegenerative diseases, which could provide a new idea for the treatment of neurodegenerative diseases in the future.
(© 2024. Huazhong University of Science and Technology.)
Databáze: MEDLINE
Externí odkaz: