Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat.
Autor: | Cannella N; School of Pharmacy, Pharmacology Unit, Center for Neuroscience, University of Camerino, Camerino, Italy. Electronic address: nazzareno.cannella@unicam.it., Tambalo S; CIMeC, Center for Mind/Brain Science, University of Trento, Trento, Italy., Lunerti V; School of Pharmacy, Pharmacology Unit, Center for Neuroscience, University of Camerino, Camerino, Italy., Scuppa G; Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy., de Vivo L; School of Pharmacy, Pharmacology Unit, Center for Neuroscience, University of Camerino, Camerino, Italy., Abdulmalek S; Faculty of Medicine, Queen's University Belfast, UK., Kinen A; School of Pharmacy, Pharmacology Unit, Center for Neuroscience, University of Camerino, Camerino, Italy; Faculty of Medicine, Queen's University Belfast, UK., Mackle J; Faculty of Medicine, Queen's University Belfast, UK., Kuhn B; Department of Neuroscience, Medical University of South Carolina (MUSC), Charleston (SC), USA., Solberg Woods LC; Wake Forest School of Medicine, Winston-Salem (NC), USA., Chung D; Department of Biomedical Informatics, The Ohio State University, Columbus (OH), USA., Kalivas P; Department of Neuroscience, Medical University of South Carolina (MUSC), Charleston (SC), USA., Soverchia L; School of Pharmacy, Pharmacology Unit, Center for Neuroscience, University of Camerino, Camerino, Italy., Ubaldi M; School of Pharmacy, Pharmacology Unit, Center for Neuroscience, University of Camerino, Camerino, Italy., Hardiman G; Faculty of Medicine, Queen's University Belfast, UK., Bifone A; Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy; Department of Molecular Biotechnology and Health Sciences, University of Torino, Italy., Ciccocioppo R; School of Pharmacy, Pharmacology Unit, Center for Neuroscience, University of Camerino, Camerino, Italy. |
---|---|
Jazyk: | angličtina |
Zdroj: | Brain, behavior, and immunity [Brain Behav Immun] 2024 May; Vol. 118, pp. 210-220. Date of Electronic Publication: 2024 Mar 06. |
DOI: | 10.1016/j.bbi.2024.03.003 |
Abstrakt: | In opioid use disorder (OUD) patients, a decrease in brain grey matter volume (GMV) has been reported. It is unclear whether this is the consequence of prolonged exposure to opioids or is a predisposing causal factor in OUD development. To investigate this, we conducted a structural MRI longitudinal study in NIH Heterogeneous Stock rats exposed to heroin self-administration and age-matched naïve controls housed in the same controlled environment. Structural MRI scans were acquired before (MRI Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |