Remarkable Improvement of Diabetic Nephropathy in Transplanted Allograft after Kidney Transplantation.

Autor:	Tanaka R; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan, ryotnk0302@gmail.com., Imamura R; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan., Matsumura S; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan., Fukae S; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan., Taniguchi A; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan., Nakazawa S; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan., Yamanaka K; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan., Namba-Hamano T; Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan., Kakuta Y; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan., Takao T; Department of Urology, Osaka General Medical Center, Osaka, Japan., Fushimi H; Department of Pathology, Osaka General Medical Center, Osaka, Japan., Nonomura N; Department of Urology, Osaka University Graduate School of Medicine, Osaka, Japan.
Jazyk:	angličtina
Zdroj:	Nephron [Nephron] 2024; Vol. 148 (7), pp. 468-473. Date of Electronic Publication: 2024 Mar 08.
DOI:	10.1159/000535877
Abstrakt:	Although glomerular damage caused by diabetic nephropathy was thought to be irreversible, in recent years, there have been reports on improvement in glomerular damage with strict glycemic control. However, few reports are available on the pathologic course after renal transplantation of donor-derived grafts with findings of diabetic nephropathy. A 53-year-old woman underwent an ABO blood-type compatible living-donor renal transplant. The recipient had no history of diabetes, and fasting blood glucose and hemoglobin A1c levels were both normal. The donor was a 57-year-old male who had received treatment for type 2 diabetes mellitus for 10 years. Transplant renal biopsy performed 1 h after revascularization showed mesangial matrix expansion and arterial hyalinosis due to diabetic nephropathy. The blood glucose level was within the normal range after transplantation. Mesangial matrix expansion and arterial hyalinosis disappeared in allograft biopsy samples 7 years after transplantation. We observed significant improvement in the pathological findings of donor-derived diabetic nephropathy after renal transplantation in the subsequent follow-ups. (© 2024 S. Karger AG, Basel.)
Databáze:	MEDLINE
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