Flagellotropic phages: common yet diverse host interaction strategies.

Autor: Gambino M; Institute of Conservation, Royal Danish Academy, Copenhagen, Denmark., Sørensen MCH; Section of Food Safety and Zoonoses, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark. Electronic address: mcp@sund.ku.dk.
Jazyk: angličtina
Zdroj: Current opinion in microbiology [Curr Opin Microbiol] 2024 Apr; Vol. 78, pp. 102451. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1016/j.mib.2024.102451
Abstrakt: Many bacteriophages (phages) interact with flagella and rely on bacterial motility for successful infection of their hosts. Yet, limited information is available on how phages have evolved to recognize and bind both flagella and subsequent surface receptors for phage DNA injection. Here, we present an update on the current knowledge of flagellotropic phages using a few well-studied phages as examples to unravel the molecular details of bacterial host recognition. We discuss the recent advances in the role of globular exposed flagellin domains and flagella glycosylation in phage binding to the flagella. In addition, we present diverse types of surface receptors and phage components responsible for the interaction with the host. Finally, we point to questions remaining to be answered and new approaches to study this unique group of phages.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The salary of M.C.H.S. was partially funded by Intralytix, Inc., but the company had no influence on the scope, outline, or content presented here.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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