Viral hepatitis-induced acute liver failure.

Autor: Biswas S; Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, 110 029, India., Kumar R; Department of Gastroenterology, All India Institute of Medical Sciences, Patna, 801 507, India., Shalimar; Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, 110 029, India. drshalimar@gmail.com., Acharya SK; Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, 110 029, India.; KIIT University, Bhubaneswar, 751 024, India.; Fortis Escorts Digestive and Liver Institute, Okhla, New Delhi, 110 025, India.
Jazyk: angličtina
Zdroj: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology [Indian J Gastroenterol] 2024 Apr; Vol. 43 (2), pp. 312-324. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1007/s12664-024-01538-w
Abstrakt: Viral hepatitis-induced acute liver failure (ALF) is a preventable cause for liver-related mortality worldwide. Viruses are the most common cause for ALF in developing nations in contrast to the west, where acetaminophen is largely responsible. Viruses may be hepatotropic or affect the liver secondary to a systemic infection. In tropical countries, infections such as leptospirosis, scrub typhus and malaria can mimic the symptoms of ALF. Differentiating these ALF mimics is crucial because they require etiology-specific therapy. Treatment of viral hepatitis-induced ALF is two-pronged and directed towards providing supportive care to prevent organ failures and antiviral drugs for some viruses. Liver transplantation (LT) is an effective modality for patients deteriorating despite adequate supportive care. Early referral and correct identification of patients who require a transplant are important. Liver support devices and plasma exchange have evolved into "bridging modalities" for LT. Preventive strategies such as hand hygiene, use of clean and potable water and inclusion of vaccines against viral hepatitis in the national program are simple yet very effective methods focusing on the preventive aspect of this disease.
(© 2024. Indian Society of Gastroenterology.)
Databáze: MEDLINE
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