Immunologic burden links periodontitis to acute coronary syndrome: levels of CD4 + and CD8 + T cells in gingival granulation tissue.

Autor: Kayar NA; Department of Periodontology, Faculty of Dentistry, Akdeniz University, Antalya, 07058, Turkey. nazu@hotmail.com., Çelik İ; Department of Biochemistry, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey., Gözlü M; Dentesthetic Oral and Dental Clinic, Konya, Turkey., Üstün K; Department of Periodontology, Faculty of Dentistry, Akdeniz University, Antalya, 07058, Turkey., Gürsel M; Department of Periodontology, Faculty of Dentistry, Bezmialem University, Istanbul, Turkey., Alptekin NÖ; Department of Periodontology, Faculty of Dentistry, Başkent University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 Mar 07; Vol. 28 (3), pp. 199. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1007/s00784-023-05448-7
Abstrakt: Objective: To investigate the proportional variation of macrophage and T-lymphocytes subpopulations in acute coronary syndrome (ACS) patients, its association with periodontitis (P), and to compare with control individuals.
Subjects and Methods: Three groups of subjects participated: one group consisted of 17 ACS patients with P (ACS + P), another group consisted of 22 no ACS + P patients, and a control group consisted of 23 participants with gingivitis (no ACS + G). Macrophage, CD4 + , and CD8 + T-lymphocytes and CD4 + /CD8 + ratio values in gingival tissue were determined histometrically.
Results: Significant differences were found among three groups regarding the mean number of macrophage (no ACS + P > ACS + P > no ACS + G; p < 0.05) and CD8 + T-lymphocytes (no ACS + P > ACS + P > no ACS + G; p < 0.05). Significant variations were observed between the groups both CD4 + T-lymphocytes densities (ACS + P > no ACS + P and ACS + P > no ACS + G; p < 0.05) and CD4 + / CD8 + ratio (no ACS + P < no ACS + G and ACS + P < no ACS + G; p < 0.05).
Conclusions: The increased number of CD8 + T-lymphocytes in both group ACS + P and group no ACS + P resulted in a reduction of the CD4 + /CD8 + ratio in gingival tissue when compared with no ACS + G group.
Clinical Relevance: The decrease of CD4 + /CD8 + ratio in gingival tissue reflects periodontitis and may be associated with severe adverse outcomes in people with ACS.
(© 2024. The Author(s).)
Databáze: MEDLINE
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