HIV Diagnostics and Vaccines: It Takes Two to Tango.

Autor:	Colón W; Johnson & Johnson Global Public Health Research and Development, Beerse, Belgium., Oriol-Mathieu V; Janssen Vaccines and Prevention B.V., Leiden, the Netherlands., Hural J; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington., Hattingh L; LH Consulting, Berkeley, California., Adungo F; Kenya Medical Research Institute, Nairobi, Kenya., Lagatie O; Johnson & Johnson Global Public Health Research and Development, Beerse, Belgium., Lavreys L; Janssen Vaccines and Prevention B.V., Leiden, the Netherlands., Allen M; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., Anzala O; Kenya Aids Vaccine Initiative Institute of Clinical Research, University of Nairobi, Kenya., Espy N; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington., Fransen K; HIV/STD Reference Laboratory, Clinical Virology Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium., Garcia PJ; Epidemiology, STD, and HIV Unit, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru., Maciel M Jr; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland., Murtagh M; The Murtagh Group, LLC, Woodside, California., Peel SA; Diagnostics and Countermeasures Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland., Peeling RW; Clinical Research Department, London School of Hygiene and Tropical Medicine, London, United Kingdom., Tan LLJ; Immunize.org, Saint Paul, Minnesota., Warren M; AVAC, New York, New York., Pau MG; Janssen Vaccines and Prevention B.V., Leiden, the Netherlands., D'Souza PM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Jun 14; Vol. 229 (6), pp. 1919-1925.
DOI:	10.1093/infdis/jiae113
Abstrakt:	Current serologic tests for HIV screening and confirmation of infection present challenges to the adoption of HIV vaccines. The detection of vaccine-induced HIV-1 antibodies in the absence of HIV-1 infection, referred to as vaccine-induced seropositivity/seroreactivity, confounds the interpretation of test results, causing misclassification of HIV-1 status with potential affiliated stigmatization. For HIV vaccines to be widely adopted with high community confidence and uptake, tests are needed that are agnostic to the vaccination status of tested individuals (ie, positive only for true HIV-1 infection). Successful development and deployment of such tests will require HIV vaccine developers to work in concert with diagnostic developers. Such tests will need to match today's high-performance standards (accuracy, cost-effectiveness, simplicity) for use in vaccinated and unvaccinated populations, especially in low- and middle-income countries with high HIV burden. Herein, we discuss the challenges and strategies for developing modified serologic HIV tests for concurrent deployment with HIV vaccines. Competing Interests: Potential conflicts of interest. W. C. and O. L. are former and current employees of Janssen Pharmaceutica N.V., respectively, and V. O. M. and M. G. P. are current employees of Janssen Vaccines and Prevention B.V. Both are Johnson & Johnson companies, and the authors may own stock or stock options in them. L. L. is a consultant for Janssen Pharmaceutica N.V. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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