Wolbachia strain wAlbB shows favourable characteristics for dengue control use in Aedes aegypti from Burkina Faso.

Autor: Mancini MV; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy., Murdochy SM; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Bilgo E; Institut de Recherche en Sciences de la Santé, Direction Régionale de l'Ouest, Dioulasso, Burkina Faso.; Institut National de Santé Publique/Centre Muraz, Dioulasso, Burkina Faso., Ant TH; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Gingell D; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Gnambani EJ; Institut de Recherche en Sciences de la Santé, Direction Régionale de l'Ouest, Dioulasso, Burkina Faso.; Institut National de Santé Publique/Centre Muraz, Dioulasso, Burkina Faso., Failloux AB; Institut Pasteur, Université Paris Cité, Arboviruses and Insect Vectors Unit, Paris, France., Diabate A; Institut de Recherche en Sciences de la Santé, Direction Régionale de l'Ouest, Dioulasso, Burkina Faso.; Institut National de Santé Publique/Centre Muraz, Dioulasso, Burkina Faso., Sinkins SP; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Jazyk: angličtina
Zdroj: Environmental microbiology [Environ Microbiol] 2024 Mar; Vol. 26 (3), pp. e16588.
DOI: 10.1111/1462-2920.16588
Abstrakt: Dengue represents an increasing public health burden worldwide. In Africa, underreporting and misdiagnosis often mask its true epidemiology, and dengue is likely to be both more widespread than reported data suggest and increasing in incidence and distribution. Wolbachia-based dengue control is underway in Asia and the Americas but has not to date been deployed in Africa. Due to the genetic heterogeneity of African Aedes aegypti populations and the complexity of the host-symbiont interactions, characterization of key parameters of Wolbachia-carrying mosquitoes is paramount for determining the potential of the system as a control tool for dengue in Africa. The wAlbB Wolbachia strain was stably introduced into an African Ae. aegypti population by introgression, and showed high intracellular density in whole bodies and different mosquito tissues; high intracellular density was also maintained following larval rearing at high temperatures. No effect on the adult lifespan induced by Wolbachia presence was detected. Moreover, the ability of this strain to strongly inhibit DENV-2 dissemination and transmission in the host was also demonstrated in the African background. Our findings suggest the potential of harnessing Wolbachia for dengue control for African populations of Ae. aegypti.
(© 2024 The Authors. Environmental Microbiology published by Applied Microbiology International and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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