| Autor: |
Ceballos-Sanchez O; Universidad de Guadalajara, Centro Universitario de Ciencias Exactas e Ingenierias (CUCEI), Departamento de Ingenieria de Proyectos, Av. José Guadalupe Zuno # 48, Industrial Los Belenes, Zapopan, Jalisco, 45157, Mexico. oscar.ceballos@academicos.udg.mx., Navarro-López DE; Tecnologico de Monterrey, Escuela de ingeniería y Ciencias, Av. Gral. Ramón Corona No 2514, Colonia Nuevo México, Zapopan, Jalisco, 45121, Mexico., Mejía-Méndez JL; Departamento de Ciencias Químico-Biológicas, Universidad de las Américas Puebla, Santa Catarina Mártir s/n, 72810 Cholula, Puebla, Mexico., Sanchez-Ante G; Tecnologico de Monterrey, Escuela de ingeniería y Ciencias, Av. Gral. Ramón Corona No 2514, Colonia Nuevo México, Zapopan, Jalisco, 45121, Mexico., Rodríguez-González V; División de Materiales Avanzados, IPICYT, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, S.L.P., Mexico., Sánchez-López AL; Tecnologico de Monterrey, Escuela de ingeniería y Ciencias, Av. Gral. Ramón Corona No 2514, Colonia Nuevo México, Zapopan, Jalisco, 45121, Mexico., Sanchez-Martinez A; Universidad de Guadalajara, Centro Universitario de Ciencias Exactas e Ingenierias (CUCEI), Departamento de Ingenieria de Proyectos, Av. José Guadalupe Zuno # 48, Industrial Los Belenes, Zapopan, Jalisco, 45157, Mexico. oscar.ceballos@academicos.udg.mx., Duron-Torres SM; Unidad Académica de Ciencias Químicas, Universidad Autónoma de Zacatecas, Campus Siglo XXI, Carretera Zacatecas, Guadalajara Km 6, Ejido La Escondida, 98160, Zacatecas, Mexico., Juarez-Moreno K; Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México (UNAM), Querétaro, QRO 76230, Mexico., Tiwari N; Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), C/Jenaro de la Fuente s/n, Campus Vida, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain., López-Mena ER; Tecnologico de Monterrey, Escuela de ingeniería y Ciencias, Av. Gral. Ramón Corona No 2514, Colonia Nuevo México, Zapopan, Jalisco, 45121, Mexico. |
| Abstrakt: |
The antioxidant capabilities of nanoparticles are contingent upon various factors, including their shape, size, and chemical composition. Herein, novel Nd-doped CeO 2 nanoparticles were synthesized and the neodymium content was varied to investigate the synergistic impact on the antioxidant properties of CeO 2 nanoparticles. Incorporating Nd 3+ induced changes in lattice parameters and significantly altered the morphology from nanoparticles to nanorods. The biological activity of Nd-doped CeO 2 was examined against pathogenic bacterial strains, breast cancer cell lines, and antioxidant models. The antibacterial and anticancer activities of nanoparticles were not observed, which could be associated with the Ce 3+ /Ce 4+ ratio. Notably, the incorporation of neodymium improved the antioxidant capacity of CeO 2 . Machine learning techniques were employed to forecast the antioxidant activity to enhance understanding and predictive capabilities. Among these models, the random forest model exhibited the highest accuracy at 96.35%, establishing it as a robust computational tool for elucidating the biological behavior of Nd-doped CeO 2 nanoparticles. This study presents the first exploration of the influence of Nd 3+ on the structural, optical, and biological attributes of CeO 2 , contributing valuable insights and extending the application of machine learning in predicting the therapeutic efficacy of inorganic nanomaterials. |
